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Pou3f2 Gene Detail
Summary
  • Symbol
    Pou3f2
  • Name
    POU domain, class 3, transcription factor 2
  • Synonyms
    9430075J19Rik, A230098E07Rik, Brn2, Brn-2, Otf7
  • Feature Type
    protein coding gene
  • IDs
    MGI:101895
    NCBI Gene: 18992
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:22482780-22488366 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 9.73 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101895
 protein coding gene Chr4:22482095-22488366 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028097
 protein coding gene Chr4:19551608-19557157 (-)
A/J MGP_AJ_G0028055
 protein coding gene Chr4:18967620-18973187 (-)
AKR/J MGP_AKRJ_G0028020
 protein coding gene Chr4:19393750-19399418 (-)
BALB/cJ MGP_BALBcJ_G0028066
 protein coding gene Chr4:19015658-19021271 (-)
C3H/HeJ MGP_C3HHeJ_G0027796
 protein coding gene Chr4:19569243-19575688 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028509
 protein coding gene Chr4:20313379-20318951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025851
 protein coding gene Chr4:17583937-17589692 (-)
CAST/EiJ MGP_CASTEiJ_G0027251
 protein coding gene Chr4:19369046-19374593 (-)
CBA/J MGP_CBAJ_G0027769
 protein coding gene Chr4:20918412-20923997 (-)
DBA/2J MGP_DBA2J_G0027912
 protein coding gene Chr4:18853158-18858754 (-)
FVB/NJ MGP_FVBNJ_G0027878
 protein coding gene Chr4:18528122-18533796 (-)
LP/J MGP_LPJ_G0028021
 protein coding gene Chr4:19638969-19644571 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027911
 protein coding gene Chr4:22138143-22145579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028568
 protein coding gene Chr4:19348875-19354477 (-)
PWK/PhJ MGP_PWKPhJ_G0026971
 protein coding gene Chr4:18677210-18682851 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026800
 protein coding gene Chr4:19181214-19187900 (-)
WSB/EiJ MGP_WSBEiJ_G0027328
 protein coding gene Chr4:19333358-19340626 (-)



Homology
more
  • Human Ortholog
    POU3F2, POU class 3 homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU3F2, POU class 3 homeobox 2
  • Synonyms
    brn-2, BRN2, N-Oct3, oct-7, OCT7, OTF7, OTF-7, POUF3
  • Links
    NCBI Gene ID: 5454
    neXtProt AC: NX_P20265
    UniProt: P20265

  • Chr Location
    6q16.1; chr6:98834574-98839458 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality by 10 days of age. Mutant animals are growth retarded, have hyperkeratotic, flaky skin, and exhibit loss of the posterior pituitary and disruption of late endocrine hypothalamic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1034
  • Tissues
    223
  • cDNA Data
    16
  • Literature Summary
    160
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000095139 Ensembl Gene Model | MGI Sequence Detail 5587 C57BL/6J ±  kb
    transcript ENSMUST00000178174 Ensembl | MGI Sequence Detail 5587 Not Applicable  
    polypeptide ENSMUSP00000136147 Ensembl | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 2
      cDNA 19
      Primer pair 7
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13082, MGD-MRK-1624, MGD-MRK-1628, MGD-MRK-18722, MGI:1924614, MGI:2443081
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 160
      Gene Ontology 16
      Phenotypes 13
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:343553 Larrigan S, et al., Divergent phenotypes in constitutive versus conditional mutant mouse models of Sifrim-Hitz-Weiss syndrome. Hum Mol Genet. 2023 Dec 1;32(24):3361-3373
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory