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Hoxc13 Gene Detail
Summary
  • Symbol
    Hoxc13
  • Name
    homeobox C13
  • Synonyms
    N
  • Feature Type
    protein coding gene
  • IDs
    MGI:99560
    NCBI Gene: 15422
  • Member of
    Hoxc cluster
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102829566-102837249 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, Syntenic
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99560
 protein coding gene Chr15:102829538-102837249 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022424
 protein coding gene Chr15:105155371-105163078 (+)
A/J MGP_AJ_G0022386
 protein coding gene Chr15:100999798-101007603 (+)
AKR/J MGP_AKRJ_G0022361
 protein coding gene Chr15:104069070-104076767 (+)
BALB/cJ MGP_BALBcJ_G0022390
 protein coding gene Chr15:101047145-101054856 (+)
C3H/HeJ MGP_C3HHeJ_G0022157
 protein coding gene Chr15:104144523-104152928 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022839
 protein coding gene Chr15:109047774-109057225 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020362
 protein coding gene Chr15:96769350-96777179 (+)
CAST/EiJ MGP_CASTEiJ_G0021683
 protein coding gene Chr15:105015504-105025127 (+)
CBA/J MGP_CBAJ_G0022126
 protein coding gene Chr15:112882663-112890374 (+)
DBA/2J MGP_DBA2J_G0022257
 protein coding gene Chr15:100269937-100277676 (+)
FVB/NJ MGP_FVBNJ_G0022233
 protein coding gene Chr15:99339465-99347150 (+)
LP/J MGP_LPJ_G0022326
 protein coding gene Chr15:105290987-105298694 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022255
 protein coding gene Chr15:116399253-116406950 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022851
 protein coding gene Chr15:104107798-104115510 (+)
PWK/PhJ MGP_PWKPhJ_G0021423
 protein coding gene Chr15:100448202-100456335 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021255
 protein coding gene Chr15:103936809-103945457 (+)
WSB/EiJ MGP_WSBEiJ_G0021733
 protein coding gene Chr15:104722292-104729853 (+)



Homology
more
  • Human Ortholog
    HOXC13, homeobox C13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXC13, homeobox C13
  • Synonyms
    ECTD9, HOX3, HOX3G
  • Links
    NCBI Gene ID: 3229
    neXtProt AC: NX_P31276
    UniProt: P31276

  • Chr Location
    12q13.13; chr12:53938831-53946544 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HOXC13 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit alopecia due to brittle hair, poor growth, abnormalities of caudal vertebrae, nails, and tongue filiform papillae, and lethality in the second week. Rare survivors recover, but lack hair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    76
  • cDNA Data
    12
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15422 NCBI Gene Model | MGI Sequence Detail 7684 C57BL/6J ±  kb
    transcript NM_010464 RefSeq | MGI Sequence Detail 2433 ZRU/MplStud  
    polypeptide P50207 UniProt | EBI | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 3
      cDNA 14
      Primer pair 9
      Other 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12776, MGD-MRK-16338, MGI:97277
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 5
      Phenotypes 46
    • Earliest
      J:14939 Lebedinsky NG, et al., Atrichosis und ihre Vererbung bei der albinotischen Hausmaus. Biol Zentralbl. 1927;47:748-52
    • Latest
      J:332853 Castilla-Ibeas A, et al., Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity. Cell Rep. 2023 Jan 13;42(1):111975
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory