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Ccl7 Gene Detail
Summary
  • Symbol
    Ccl7
  • Name
    C-C motif chemokine ligand 7
  • Synonyms
    fic, marc, mcp3, MCP-3, Scya7
  • Feature Type
    protein coding gene
  • IDs
    MGI:99512
    NCBI Gene: 20306
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:81936538-81938351 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 49.83 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99512
 protein coding gene Chr11:81936538-81938351 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018822
 protein coding gene Chr11:83289745-83291558 (+)
A/J MGP_AJ_G0018789
 protein coding gene Chr11:80088666-80090479 (+)
AKR/J MGP_AKRJ_G0018759
 protein coding gene Chr11:82480710-82482523 (+)
BALB/cJ MGP_BALBcJ_G0018762
 protein coding gene Chr11:80482520-80484333 (+)
C3H/HeJ MGP_C3HHeJ_G0018576
 protein coding gene Chr11:82532734-82534547 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019214
 protein coding gene Chr11:85787932-85789745 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016848
 protein coding gene Chr11:77059530-77061330 (+)
CAST/EiJ MGP_CASTEiJ_G0018131
 protein coding gene Chr11:83083151-83084964 (+)
CBA/J MGP_CBAJ_G0018547
 protein coding gene Chr11:89552725-89554538 (+)
DBA/2J MGP_DBA2J_G0018655
 protein coding gene Chr11:79649686-79651499 (+)
FVB/NJ MGP_FVBNJ_G0018644
 protein coding gene Chr11:79197305-79199118 (+)
LP/J MGP_LPJ_G0018725
 protein coding gene Chr11:83814057-83815870 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018671
 protein coding gene Chr11:89730649-89732462 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019254
 protein coding gene Chr11:82750430-82752243 (+)
PWK/PhJ MGP_PWKPhJ_G0017901
 protein coding gene Chr11:80475128-80476942 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017692
 protein coding gene Chr11:82361109-82362922 (+)
WSB/EiJ MGP_WSBEiJ_G0018183
 protein coding gene Chr11:82624525-82626339 (+)



Homology
more
  • Human Ortholog
    CCL7, C-C motif chemokine ligand 7
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL7, C-C motif chemokine ligand 7
  • Synonyms
    FIC, MARC, MCP3, MCP-3, NC28, SCYA6, SCYA7
  • Links
    NCBI Gene ID: 6354
    neXtProt AC: NX_P80098
    UniProt: P80098

  • Chr Location
    17q12; chr17:34270221-34272242 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CCL7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit alterations in blood monocyte counts and in the monocytic response to thioglycollate-induced inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    36
  • cDNA Data
    14
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20306 NCBI Gene Model | MGI Sequence Detail 1814 C57BL/6J ±  kb
transcript NM_013654 RefSeq | MGI Sequence Detail 912 ZRU/MplStud  
polypeptide Q03366 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 5
    cDNA 14
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16289
References
more
  • Summaries
    All 88
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 27
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:314009 Xue J, et al., Astrocyte-derived CCL7 promotes microglia-mediated inflammation following traumatic brain injury. Int Immunopharmacol. 2021 Oct;99:107975
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory