About   Help   FAQ
Sat1 Gene Detail
Summary
  • Symbol
    Sat1
  • Name
    spermidine/spermine N1-acetyl transferase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98233
    NCBI Gene: 20229
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:153996128-153999445 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 72.38 cM, cytoband F3-F4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98233
 protein coding gene ChrX:153996122-153999445 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036211
 protein coding gene ChrX:153103851-153107157 (-)
A/J MGP_AJ_G0036181
 protein coding gene ChrX:152381567-152384909 (-)
AKR/J MGP_AKRJ_G0036109
 protein coding gene ChrX:157197064-157200494 (-)
BALB/cJ MGP_BALBcJ_G0036174
 protein coding gene ChrX:150482660-150485969 (-)
C3H/HeJ MGP_C3HHeJ_G0035880
 protein coding gene ChrX:153435941-153439245 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036696
 protein coding gene ChrX:157561336-157564651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033516
 protein coding gene ChrX:143962810-143966111 (-)
CAST/EiJ MGP_CASTEiJ_G0035168
 protein coding gene ChrX:132597582-132601175 (-)
CBA/J MGP_CBAJ_G0035855
 protein coding gene ChrX:162048955-162052272 (-)
DBA/2J MGP_DBA2J_G0036021
 protein coding gene ChrX:151385915-151389229 (-)
FVB/NJ MGP_FVBNJ_G0035951
 protein coding gene ChrX:150496522-150499832 (-)
LP/J MGP_LPJ_G0036106
 protein coding gene ChrX:154199052-154202366 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035984
 protein coding gene ChrX:170411471-170414783 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036737
 protein coding gene ChrX:152683855-152687195 (-)
PWK/PhJ MGP_PWKPhJ_G0034866
 protein coding gene ChrX:129584832-129588195 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034687
 protein coding gene ChrX:133048797-133051873 (-)
WSB/EiJ MGP_WSBEiJ_G0035303
 protein coding gene ChrX:150680810-150684120 (-)



Homology
more
  • Human Ortholog
    SAT1, spermidine/spermine N1-acetyltransferase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAT1, spermidine/spermine N1-acetyltransferase 1
  • Synonyms
    DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1
  • Links
    NCBI Gene ID: 6303
    neXtProt AC: NX_P21673
    UniProt: P21673

  • Chr Location
    Xp22.11; chrX:23783173-23786210 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced female fertility, increased percent body fat and total fat pad weight, abnormal liver and white adipose tissue physiology, abnormal aerobic energy metabolism, increased serum leptin levels, and increased weight gain on a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    117
  • cDNA Data
    14
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025283 Ensembl Gene Model | MGI Sequence Detail 3318 C57BL/6J ±  kb
    transcript ENSMUST00000112551 Ensembl | MGI Sequence Detail 896 Not Applicable  
    polypeptide ENSMUSP00000108170 Ensembl | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 5
      cDNA 16
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14295, MGI:2146776
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 33
    • Earliest
      J:3224 de Meeus A, et al., A detailed linkage map of subtelomeric murine chromosome 12 region including the situs inversus mutation locus IV. Mamm Genome. 1992;3(11):637-43
    • Latest
      J:326958 Sapir T, et al., Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. Nat Commun. 2022 Jul 21;13(1):4209
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory