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Gene Expression Data
Assay Details
Assay
Reference: J:65295 Barallobre MJ, et al., Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice. Development. 2000 Nov;127(22):4797-810
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7751860
Gene symbol: Dcc
Gene name: DCC netrin 1 receptor
Antibody: anti-DCC
Detection system: Secondary antibody coupled to horseradish peroxidase
Assay notes: The authors did not specify which antibody was used, MGI:7751859 may have been used instead.
Results
Specimen 1C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: brain white matter Present Regionally restricted 1C There are immunoreactive fiber bundles in the white matter.
TS24: hippocampus Present Regionally restricted 1C Expression is in the fimbria.

Specimen 1E: embryonic day 16.5 (more )
Note: Double labeled: brown - Dcc; blue - Ntn1 (assay MGI:7751854).
Structure Level Pattern Image Note
TS24: hippocampus Present Regionally restricted 1E Expression is in the fimbria.

Specimen 1F: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: hippocampal commissure Present 1F

Specimen 3A: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: hippocampal commissure Very strong 3A
TS27: fimbria hippocampus Present 3A
TS27: white matter Present 3A
TS27: hippocampus stratum oriens Weak 3A
TS27: hippocampus stratum radiatum Weak 3A
TS27: hippocampus molecular layer Trace 3A
TS27: hippocampus stratum lacunosum Trace 3A

Specimen 3C: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: telencephalon Present Regionally restricted 3C Expression is in fibers crossing the midline.
TS27: telencephalon septum Weak Regionally restricted 3C There is weak dorsal expression and is absent in fascicles.

Specimen 3D: postnatal day 0; Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg (more )
Structure Level Pattern Image Note
TS27: brain white matter Present Regionally restricted 3D Immunoreactive fiber bundles are disorganized in the white matter.
TS27: fimbria hippocampus Present 3D Immunoreactive fiber bundles are disorganized.
TS27: hippocampus layer Present Regionally restricted 3D Staining is in ectopic fiber fascicles.
TS27: dentate gyrus granule cell layer Present Regionally restricted 3D Staining is in ectopic fiber fascicles.

Specimen 3F: postnatal day 0; Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg (more )
Structure Level Pattern Image Note
TS27: brain white matter Present 3F Positive fibers curve towards the septum.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory