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Gene Expression Data
Assay Details
Assay
Reference: J:353361 Yu H, et al., The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice. Mol Metab. 2024 Sep;87:101993
Assay type: RNA in situ
MGI Accession ID: MGI:7717798
Gene symbol: Six3
Gene name: sine oculis-related homeobox 3
Probe: Mm-Six3 (412941)
Probe preparation: Antisense DNA
Visualized with: Fluorescence
Results
Specimen 1E E12.5 Six3: embryonic day 12.5 (more )
Note: Double labeled: red - Six3; green - Pomc (assay MGI:7717797).
Structure Cell Type Level Pattern Image Note
TS20: hypothalamus neuron Present Regionally restricted 1E E12.5 Six3 inset , 1E E12.5 Merged , 1E E12.5 Six3 , 1E E12.5 Merged inset Expression in basal hypothalamic region in Pomc-expressing neurons throughout development and adulthood.
Specimen S1 E14.5 Six3: embryonic day 14.5 (more )
Note: Double labeled: red - Six3; green - Pomc (assay MGI:7717797).
Structure Cell Type Level Pattern Image Note
TS22: hypothalamus neuron Present Regionally restricted S1_E14.5 Six3 , S1_E14.5 Six3 inset , S1_E14.5 Merged inset , S1_E14.5 Merged Expression in basal hypothalamic region in Pomc-expressing neurons throughout development and adulthood.
Specimen 1E E16.5 Six3: embryonic day 16.5 (more )
Note: Double labeled: red - Six3; green - Pomc (assay MGI:7717797).
Structure Cell Type Level Pattern Image Note
TS24: hypothalamus neuron Present Regionally restricted 1E E16.5 Six3 , 1E E16.5 Six3 inset , 1E E16.5 Merged inset , 1E E16.5 Merged Expression in basal hypothalamic region in Pomc-expressing neurons throughout development and adulthood.
Specimen S1 E18.5 Six3: postnatal adult (more )
Note: Double labeled: red - Six3; green - Pomc (assay MGI:7717797).
Structure Cell Type Level Pattern Image Note
TS28: hypothalamus neuron Present Regionally restricted S1_Adult Six3 , S1_Adult Merged , S1_Adult Six3 inset , S1_Adult Merged inset Expression in basal hypothalamic region in Pomc-expressing neurons throughout development and adulthood.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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