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Gene Expression Data
Assay Details
Assay
Reference: J:65195 Stoykova A, et al., Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci. 2000 Nov 1;20(21):8042-50
Assay type: RNA in situ
MGI Accession ID: MGI:7620205
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Probe: Tbr1 probe
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 1F: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: pallium neuron Present Regionally restricted 1F Expression is in early postmitotic cells.
TS20: ventral pallium neuron Present Regionally restricted 1F Expression is in early postmitotic cells.
TS20: telencephalon Present Regionally restricted 1F Expression is in cells that extend out from the neuroepithelium of the ventral pallium toward the basolateral telencephalon.

Specimen 1F': embryonic day 12.5; Pax6Sey/Pax6Sey (more )
Structure Cell Type Level Pattern Image Note
TS20: ventral pallium Present Regionally restricted 1F' In this mutant expression is absent in the subventricular zone, submantle, and mantle zone.
TS20: pallium neuron Present Regionally restricted 1F' In this mutant expression is less affected in the postmitotic neurons of the preplate in the dorsal and lateral pallium.

Specimen 4A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: neocortex Present Regionally restricted 4A Expression is in postmitotic cells.
TS26: paleocortex Present Regionally restricted 4A Expression is in postmitotic cells.
TS26: brain nucleus Present Regionally restricted 4A Expression is in classical claustrum.

Specimen 4B: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: neocortex Present Regionally restricted 4B Expression is in postmitotic cells.
TS26: paleocortex Present Regionally restricted 4B Expression is in postmitotic cells.
TS26: piriform cortex Present Regionally restricted 4B Expression is in the dense layer II.

Specimen 4G: embryonic day 18.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS26: telencephalon Present 4G Expression pattern is altered due to indistinguishable structures.

Specimen 6E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present 6E
TS26: lateral pallium Present 6E
TS26: ventral pallium Present 6E

Specimen 6E': embryonic day 18.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS26: telencephalon Present 6E'
TS26: lateral pallium Absent 6E'
TS26: ventral pallium Absent 6E'

Specimen not shown WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cortical plate Weak Regionally restricted Expression is in the superficial zone of the forming cortical plate.

Specimen not shown Sey/Sey: embryonic day 14.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS22: cerebral cortex subventricular zone Absent
TS22: cerebral cortex ventricular layer Absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory