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Gene Expression Data
Assay Details
Assay
Reference: J:299667 Calame DJ, et al., Presynaptic PRRT2 Deficiency Causes Cerebellar Dysfunction and Paroxysmal Kinesigenic Dyskinesia. Neuroscience. 2020 Nov 10;448:272-286
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7610588
Gene symbol: Prrt2
Gene name: proline-rich transmembrane protein 2
Antibody: Anti-PRRT2 (HPA014447)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4B +/+: postnatal (more )
Note: Double labeled: green - Prrt2; red - Calb1 (assay MGI:7610587).
Structure Level Pattern Image Note
TS28: cerebellum granule cell layer Present 4B +/+
TS28: cerebellum molecular layer Present 4B +/+
TS28: cerebellum Purkinje cell layer Absent 4B +/+ No colocalization with calbindin was seen.
Specimen 4B -/-: postnatal; Prrt2tm1d(KOMP)Wtsi/Prrt2tm1d(KOMP)Wtsi (more )
Note: Double labeled: green - Prrt2; red - Calb1 (assay MGI:7610587).
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Absent 4B -/-
TS28: cerebellum granule cell layer Absent 4B -/-
TS28: cerebellum molecular layer Absent 4B -/-
Specimen 4D +/+: postnatal (more )
Note: Double labeled: green - Prrt2; red - Slc17a7 (assay MGI:7610589).
Structure Level Pattern Image Note
TS28: cerebellum granule cell layer Present 4D +/+ PRRT2 , 4D +/+ merge Highly colocalized with vGlut1/Slc17a7.
TS28: cerebellum molecular layer Present 4D +/+ PRRT2 , 4D +/+ merge Highly colocalized with vGlut1/Slc17a7.
Specimen 4D -/-: postnatal; Prrt2tm1d(KOMP)Wtsi/Prrt2tm1d(KOMP)Wtsi (more )
Note: Double labeled: green - Prrt2; red - Slc17a7 (assay MGI:7610589).
Structure Level Pattern Image Note
TS28: cerebellum granule cell layer Absent 4D -/- PRRT2 , 4D -/- merge
TS28: cerebellum molecular layer Absent 4D -/- PRRT2 , 4D -/- merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory