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Gene Expression Data
Assay Details
Assay
Reference: J:261178 Yousaf R, et al., Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. J Clin Invest. 2018 Apr 2;128(4):1509-1522
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7610075
Gene symbol: Gab1
Gene name: growth factor receptor bound protein 2-associated protein 1
Reporter: lacZ
Direct Detection
Assay notes: Fixative was 1% formaldehyde, 0.2% glutaraldehyde
Results
Specimen 4A Cochlea: postnatal day 0; Gab1tm1Thir/Gab1+ (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlea organ of Corti supporting cell Present Regionally restricted 4A
TS27: cochlear ganglion spiral ganglion neuron Present 4A
TS27: spiral limbus Present 4A
TS27: organ of Corti cochlear inner hair cell Absent 4A No detectable expression in inner or outer hair cells.
TS27: organ of Corti cochlear outer hair cell Absent 4A No detectable expression in inner or outer hair cells.
Specimen 4B Ampulla: postnatal day 0; Gab1tm1Thir/Gab1+ (more )
Structure Level Pattern Image Note
TS27: semicircular duct ampulla Present Regionally restricted 4B Expression in sensory epithelium. Expression in transition cells. Little or no expression in nonsensory epitheium
Specimen 4C Utricle: postnatal day 0; Gab1tm1Thir/Gab1+ (more )
Structure Level Pattern Image Note
TS27: utricle epithelium Present Regionally restricted 4C Expression in sensory epithelium. Little or no expression in nonsensory epitheium.
Specimen 4D Apical: postnatal day 0; Gab1tm1Thir/Gab1+ (more )
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti organ of Corti supporting cell Present Regionally restricted 4D Apical
TS27: cochlear ganglion spiral ganglion neuron Present 4D Apical
TS27: external spiral sulcus Present 4D Apical
TS27: internal spiral sulcus Present 4D Apical
TS27: spiral limbus Present 4D Apical
Specimen 4D Middle: postnatal day 0; Gab1tm1Thir/Gab1+ (more )
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti organ of Corti supporting cell Present 4D Middle
TS27: external spiral sulcus Present 4D Middle
TS27: internal spiral sulcus Present 4D Middle
TS27: spiral limbus Present 4D Middle
Specimen 4D Basal: postnatal day 0; Gab1tm1Thir/Gab1+ (more )
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti organ of Corti supporting cell Present Regionally restricted 4D Basal
TS27: external spiral sulcus Present 4D Basal
TS27: internal spiral sulcus Present 4D Basal
TS27: spiral limbus Present 4D Basal
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory