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Gene Expression Data
Assay Details
Assay
Reference: J:262420 Szenker-Ravi E, et al., RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Nature. 2018 May;557(7706):564-569
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7606802
Gene symbol: Lgr6
Gene name: leucine-rich repeat-containing G protein-coupled receptor 6
Reporter: GFP
Antibody: anti-GFP
Results
Specimen 2i Triple KO (left): embryonic day 14.5; Lgr4tm1(cre/ERT2)Cle/Lgr4tm1(cre/ERT2)Cle, Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa, Lgr6tm2.1(cre/ERT2)Cle/Lgr6tm2.1(cre/ERT2)Cle (more )
Note: Double labeled: green - Lgr6 and Lgr4 and Lgr5 reporter; red - Vim (assay MGI:7596300).
Structure Level Pattern Image Note
TS22: lung Present Regionally restricted 2i Lgr4/5/6 -/- Vimentin Expression in single layer of Vim-expressing cells adjacent to Cdh1-expressing epithelium.
Specimen 2i Triple KO inset (left): embryonic day 14.5; Lgr4tm1(cre/ERT2)Cle/Lgr4tm1(cre/ERT2)Cle, Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa, Lgr6tm2.1(cre/ERT2)Cle/Lgr6tm2.1(cre/ERT2)Cle (more )
Note: Double labeled: green - Lgr6 and Lgr4 and Lgr5 reporter; red - Vim (assay MGI:7596300).
Structure Level Pattern Image Note
TS22: lung Present Regionally restricted 2i Lgr4/5/6 -/- Vimentin inset Expression in single layer of Vim-expressing cells adjacent to Cdh1-expressing epithelium.
Specimen 2i Triple KO (right): embryonic day 14.5; Lgr4tm1(cre/ERT2)Cle/Lgr4tm1(cre/ERT2)Cle, Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa, Lgr6tm2.1(cre/ERT2)Cle/Lgr6tm2.1(cre/ERT2)Cle (more )
Note: Double labeled: green - Lgr6 and Lgr4 and Lgr5 reporter; red - Cdh1 (assay MGI:7596301).
Structure Level Pattern Image Note
TS22: lung Present Regionally restricted 2i Lgr4/5/6 -/- E-cadherin Expression in single layer of Vim-expressing cells adjacent to Cdh1-expressing epithelium.
Specimen 2i Triple KO inset (right): embryonic day 14.5; Lgr4tm1(cre/ERT2)Cle/Lgr4tm1(cre/ERT2)Cle, Lgr5tm1.1(cre/ERT2)Npa/Lgr5tm1.1(cre/ERT2)Npa, Lgr6tm2.1(cre/ERT2)Cle/Lgr6tm2.1(cre/ERT2)Cle (more )
Note: Double labeled: green - Lgr6 and Lgr4 and Lgr5 reporter; red - Cdh1 (assay MGI:7596301).
Structure Level Pattern Image Note
TS22: lung Present Regionally restricted 2i Lgr4/5/6 -/- E-cadherin inset Expression in single layer of Vim-expressing cells adjacent to Cdh1-expressing epithelium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory