Gene Expression Data
Assay Details
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Assay
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Reference:
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J:150356
Jacobs FM, et al., Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Development. 2009 Jul;136(14):2363-73
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:7596519
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Gene symbol:
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Dlk1
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Gene name:
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delta like non-canonical Notch ligand 1
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Probe:
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Dlk1 probe
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Probe preparation:
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Antisense labelled with digoxigenin RNA
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Results
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Specimen
4B:
embryonic day 14.5
(more  )
Specimen
4B:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: midbrain |
Present |
Regionally restricted |
4B
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Expressed in the mesodiencephalic dopamine neuronal field, but was clearly restricted to the caudal domain in these medial sections.
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Specimen
5C:
postnatal adult
(more )
Specimen
5C:
(close )
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Genetic Background:
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Not Specified
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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section
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Specimen
6B:
embryonic day 14.5
(more )
Specimen
6B:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: midbrain |
Present |
Regionally restricted |
6B
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Expressed in the mesodiencephalic dopamine neuronal field.
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Specimen
6B':
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd
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Mutant Allele(s):
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Nr4a2tm1Omc/Nr4a2tm1Omc
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: midbrain |
Present |
Regionally restricted |
6B'
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Substantially reduced expression in the mesodiencephalic dopamine neuronal field, compared with the wild-type. Only retained in a selective population of neurons along the midline.
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| TS22: brain |
Present |
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6B'
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Only the expression in the mesodiencephalic dopamine neuronal field was affected in the mutant, as expression in other structures in the brain was unaffected.
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Specimen
6J:
embryonic day 14.5
(more )
Specimen
6J:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: midbrain |
Present |
Regionally restricted |
6J
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Expressed in the mesodiencephalic dopamine neuronal field.
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Specimen
6J':
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd
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Mutant Allele(s):
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Nr4a2tm1Omc/Nr4a2tm1Omc
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: midbrain |
Present |
Regionally restricted |
6J'
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Substantially reduced expression in the mesodiencephalic dopamine neuronal field, compared with the wild-type. Only retained in a selective population of neurons along the midline.
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Specimen
7D:
embryonic day 14.5
(more )
Specimen
7D:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: midbrain |
Present |
Regionally restricted |
7D
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Expressed in the mesodiencephalic dopamine neuronal field, but was clearly restricted to the caudal domain in these medial sections.
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Specimen
7D':
(close )
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Genetic Background:
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involves: 129S1/Sv
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Mutant Allele(s):
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Pitx3ak/Pitx3ak
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: midbrain |
Present |
Regionally restricted |
7D'
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Expression in the mesodiencephalic dopamine neuronal field remained, even expanded into anterior positions.
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Specimen
8L:
embryonic day 14.5
(more )
Specimen
8L:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Specimen
8P:
embryonic day 14.5
(more )
Specimen
8P:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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