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Gene Expression Data
Assay Details
Assay
Reference: J:190564 Tavares AL, et al., Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol. 2012 Nov 1;371(1):47-56
Assay type: RNA in situ
MGI Accession ID: MGI:7580436
Gene symbol: Nkx3-2
Gene name: NK3 homeobox 2
Probe: Nkx3-2 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 7C: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 7C Expression confined to caudal region in central mandibular arch mesenchyme.
TS17: 1st branchial arch ectoderm Present Regionally restricted 7C Expression in a small region along rostral arch ectoderm.
Specimen 7D: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 7D Expression down regulated in caudal mandibular arch mesenchyme.
TS17: 1st branchial arch ectoderm Present Regionally restricted 7D Expression in arch ectoderm is unaffected.
Specimen 7E: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa (more )
Note: Double labeled: blue - Nkx3-2; magenta - Dlx5 (assay MGI:7580433).
Structure Level Pattern Image Note
TS17: 1st branchial arch Present Regionally restricted 7E Expression contained within Dlx5 expression domain.
Specimen 7F: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant. Double labeled: blue - Nkx3-2; magenta - Dlx5 (assay MGI:7580433).
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Trace Regionally restricted 7F Residual mesenchyme expression confined to domain in which Dlx5 is absent.
Specimen 7I: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa (more )
Note: Double labeled: blue - Nkx3-2; magenta - Dlx3 (assay MGI:7580431).
Structure Level Pattern Image Note
TS17: 1st branchial arch Present Regionally restricted 7I Expression confined within Dlx3 mesenchyme domain.
Specimen 7J: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant. Double labeled: blue - Nkx3-2; magenta - Dlx3 (assay MGI:7580431).
Structure Level Pattern Image Note
TS17: 1st branchial arch Present Regionally restricted 7J Expression overlapping with Dlx3 is absent.
Specimen 8C: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch Present Regionally restricted 8C
Specimen 8D: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa, Tg(Tcfap2a-cre)1Will/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 8D Mesenchymal expression disrupted in mandibular arch.
TS17: 1st branchial arch ectoderm Present Regionally restricted 8D Epithelial expression unaffected compared to control.
Specimen 8E: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa (more )
Note: Double labeled: blue - Nkx3-2; magenta - Dlx5 (assay MGI:7580433).
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 8E Mesenchymal expression overlaps with that of Dlx5.
Specimen 8F: embryonic day 10.5; Edn1tm1Ywa/Edn1tm1Ywa, Tg(Tcfap2a-cre)1Will/0 (more )
Note: Conditional mutant. Double labeled: blue - Nkx3-2; magenta - Dlx5 (assay MGI:7580433).
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 8F Mesenchymal expression largely absent from domain in which Dlx5 expression has been lost.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory