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Gene Expression Data
Assay Details
Assay
Reference: J:342123 Sterling NA, et al., P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7548373
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6 (#PRB-278P; #30130, #901301)
Detection system: Secondary antibody
Results
Specimen 4D PAX6 WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4D WT Expression in apical radial glia progenitors.
Specimen 4D PAX6 Trp53 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4D Trp53 cKO
Specimen 4D PAX6 BubR1 cKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Weak 4D BubR1 cKO Expression significantly reduced compared to wild type.
Specimen 4D PAX6 dcKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4D dcKO Expression partially rescued but not to wild type levels.
Specimen 4H PAX6 WT: embryonic day 14.5 (more )
Note: Double labeled: red - Pax6; green - BrdU.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4H WT
Specimen 4H PAX6 Trp53 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: red - Pax6; green - BrdU.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4H Trp53 cKO
Specimen 4H PAX6 BubR1 cKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Pax6; green - BrdU.
Structure Level Pattern Image Note
TS22: cerebral cortex Weak 4H BubR1 cKO Expression reduced compared to wild type.
Specimen 4H PAX6 dcKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: red - Pax6; green - BrdU.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 4H dcKO
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory