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Gene Expression Data
Assay Details
Assay
Reference: J:342123 Sterling NA, et al., P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7548370
Gene symbol: Foxm1
Gene name: forkhead box M1
Antibody: Anti-phospho-Ser/Thr-Pro MPM-2 (05-368MG)
Detection system: Secondary antibody
Results
Specimen 3A MMP2 WT: embryonic day 14.5 (more )
Note: Double labeled: green - Foxm1; red - Casp3 (assay MGI:7548368).
Structure Level Pattern Image Note
TS22: cerebral cortex Present 3A WT , 3A WT inset Expression in mitotic cells.
Specimen 3A MMP2 Trp53 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: green - Foxm1; red - Casp3 (assay MGI:7548368).
Structure Level Pattern Image Note
TS22: cerebral cortex Present 3A Trp53 cKO inset , 3A Trp53 cKO
Specimen 3A MMP2 BubR1 cKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Foxm1; red - Casp3 (assay MGI:7548368).
Structure Level Pattern Image Note
TS22: cerebral cortex Strong Regionally restricted 3A BubR1 cKO inset , 3A BubR1 cKO Proportion of expressing cells undergoing cell death significantly higher than in wild type.
Specimen 3A MMP2 dcKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: green - Foxm1; red - Casp3 (assay MGI:7548368).
Structure Level Pattern Image Note
TS22: cerebral cortex Present 3A dcKO , 3A dcKO inset Proportion of expressing cells undergoing cell death reduced compared to BubR1 cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory