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Gene Expression Data
Assay Details
Assay
Reference: J:342123 Sterling NA, et al., P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7548367
Gene symbol: Adgre1
Gene name: adhesion G protein-coupled receptor E1
Antibody: anti-F4/80 (28463-1-AP)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2C F4/80 WT: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex microglial cell Present 2C WT Expression in activated microglia.
Specimen 2C F4/80 Trp53 cKO: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 2C Trp53 cKO
Specimen 2C F4/80 BubR1 cKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Strong 2C BubR1 cKO Number of expressing cells signficantly increased compared to wild type.
Specimen 2C F4/80 dcKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 2C dcKO Expression at wild type levels.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory