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Gene Expression Data
Assay Details
Assay
Reference: J:221086 Patra D, et al., Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. PLoS One. 2014;9(8):e105674
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7537307
Gene symbol: Comp
Gene name: cartilage oligomeric matrix protein
Antibody: anti-COMP
Detection system: Secondary antibody
Results
Specimen 3B/C: embryonic day 16.5; Mbtps1tm1Jdh/Mbtps1tm1Jdh (more )
Note: Double labeled: red - Comp; green - Canx (assay MGI:7537301).
Structure Level Pattern Image Note
TS24: femur Present Regionally restricted 3B , 3C Expression in cartilage, distinct from that of Canx.
Specimen 3E/F: embryonic day 16.5; Mbtps1tm1Jdh/Mbtps1tm1Jdh, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant. Double labeled: red - Comp; green - Canx (assay MGI:7537301).
Structure Level Pattern Image Note
TS24: femur Present Regionally restricted 3E , 3F Expression in cartilage, distinct from that of Canx.detected intracellularly.
Specimen 3G: embryonic day 16.5; Mbtps1tm1Jdh/Mbtps1tm1Jdh (more )
Note: Double labeled: green - Comp; red - Col2a1 (assay MGI:7537302).
Structure Level Pattern Image Note
TS24: femur Present Regionally restricted 3G Expression overlapping with that of Col II in matrix. Very little expression detected intracellularly.
Specimen 3H: embryonic day 16.5; Mbtps1tm1Jdh/Mbtps1tm1Jdh, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant. Double labeled: green - Comp; red - Col2a1 (assay MGI:7537302).
Structure Level Pattern Image Note
TS24: femur Present Regionally restricted 3H Expression in matrix appears disordered and filamentous, with expression domain distinct from that of Col II. Some expression also trapped in endoplasmic reticulum (ER) of chondrocytes - usually very small aggregates surrounded by larger Col II aggregates.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory