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Gene Expression Data
Assay Details
Assay
Reference: J:336094 Zheng H, et al., CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation. Development. 2023 May 15;150(10):dev200848
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7532832
Gene symbol: Mdm2
Gene name: transformed mouse 3T3 cell double minute 2
Antibody: Anti-MDM2 ab226939
Detection system: Secondary antibody
Assay notes: An in situ proximity ligation assay (PLA) using MDM2 and DLX3 antibodies.
Results
Specimen 7Fc: postnatal day 14 (more )
Note: Red fluorescent signals represent the presence of protein interaction.
Structure Cell Type Level Pattern Image Note
TS28: incisor mesenchyme mesenchymal cell Weak Regionally restricted 7Fc Proximity ligation assay indicated that the interaction between MDM2 and DLX3 was weak in undifferentiated dental mesenchymal cells.
Specimen 7Fd: postnatal day 14 (more )
Note: Red fluorescent signals represent the presence of protein interaction.
Structure Cell Type Level Pattern Image Note
TS28: incisor odontoblast Present Regionally restricted 7Fd Proximity ligation assay indicated that the interaction between MDM2 and DLX3 was enhanced in the secretory odontoblasts.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory