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Gene Expression Data
Assay Details
Assay
Reference: J:132979 Potok MA, et al., WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn. 2008 Apr;237(4):1006-20
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7526036
Gene symbol: Pomc
Gene name: pro-opiomelanocortin-alpha
Antibody: anti-POMC
Detection system: Secondary antibody coupled to fluorescein
Results
Specimen 2A: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: adenohypophysis pars anterior corticotroph Present 2A Expression in anterior lobe marking differentiated corticotropes.
TS24: adenohypophysis pars intermedia melanocyte stimulating hormone secreting cell Present 2A Expression in intermediate lobe marking differentiated melanotropes.
Specimen 2B: embryonic day 16.5; Wnt4tm1Amc/Wnt4tm1Amc (more )
Structure Cell Type Level Pattern Image Note
TS24: adenohypophysis pars anterior corticotroph Present 2B Expression unchanged compared to wild-type.
TS24: adenohypophysis pars intermedia melanocyte stimulating hormone secreting cell Present 2B Expression unchanged compared to wild-type.
Specimen 4Bq: embryonic day 18.5; Wnt4tm1Amc/Wnt4+, Wnt5atm1Amc/Wnt5a+ (more )
Structure Level Pattern Image Note
TS26: adenohypophysis pars intermedia Present 4Bq Expression in intermediate lobe appears normal.
Specimen 4Br: embryonic day 18.5; Wnt4tm1Amc/Wnt4tm1Amc (more )
Structure Level Pattern Image Note
TS26: adenohypophysis pars intermedia Present 4Br Expression in intermediate lobe appears normal.
Specimen 4Bs: embryonic day 18.5; Wnt5atm1Amc/Wnt5atm1Amc (more )
Structure Cell Type Level Pattern Image Note
TS26: adenohypophysis pars intermedia corticotroph Present Regionally restricted 4Bs Expression in corticotropes and melanotropes in dysmorphic region.
TS26: adenohypophysis pars intermedia melanocyte stimulating hormone secreting cell Present Regionally restricted 4Bs Expression in corticotropes and melanotropes in dysmorphic region.
Specimen 4Bt: embryonic day 18.5; Wnt4tm1Amc/Wnt4tm1Amc, Wnt5atm1Amc/Wnt5atm1Amc (more )
Structure Level Pattern Image Note
TS26: adenohypophysis pars intermedia Present 4Bt Expression in intermediate lobe appears normal.
Specimen 5 POMC +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: adenohypophysis Present 5_POMC +/+
Specimen 5 POMC -/-: embryonic day 18.5; Wnt6tm1Akis/Wnt6tm1Akis (more )
Structure Level Pattern Image Note
TS26: adenohypophysis Present 5_POMC -/- Expression unchanged compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory