Irx2 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:92061 Eng SR, et al., Coordinated regulation of gene expression by Brn3a in developing sensory ganglia. Development. 2004 Aug;131(16):3859-70
Assay type:	RNA in situ
MGI Accession ID:	MGI:7521945
Gene symbol:	Irx2
Gene name:	Iroquois homeobox 2

Probe:	Irx2 probe3
Probe preparation:	Antisense labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

3A Irx2 +/+ ©

Specimen 3A Irx2 +/+: embryonic day 13.5 (more

)

Structure	Level	Image	Note
TS21: vestibulo-cochlear ganglion	Present	3A Irx2 +/+
TS21: glossopharyngeal ganglion	Trace	3A Irx2 +/+	Weak to undetectable expression in trigeminal and IX ganglia
TS21: trigeminal ganglion	Trace	3A Irx2 +/+	Weak to undetectable expression in trigeminal and IX ganglia

Specimen Irx2 +/+ not shown: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: dorsal root ganglion	Trace			Weak to undetectable expression in dorsal root ganglion

3A Irx2 -/- ©

Specimen 3A Irx2 -/-: embryonic day 13.5; Pou4f1^tm1Nat/Pou4f1^tm1Nat (more

)

Structure	Level	Image	Note
TS21: glossopharyngeal ganglion	Strong	3A Irx2 -/-	Expression markedly increased in trigeminal ganglion and IX/X complex compared to control.
TS21: trigeminal ganglion	Strong	3A Irx2 -/-	Expression markedly increased in trigeminal ganglion and IX/X complex compared to control.
TS21: vagus ganglion	Strong	3A Irx2 -/-	Expression markedly increased in trigeminal ganglion and IX/X complex compared to control.

Specimen Irx2 -/- not shown: embryonic day 13.5; Pou4f1^tm1Nat/Pou4f1^tm1Nat (more

)

Structure	Level	Pattern	Image	Note
TS21: dorsal root ganglion	Trace			Expression not increased in dorsal root ganglion compared to control.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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