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Gene Expression Data
Assay Details
Assay
Reference: J:338176 Guth SI, et al., Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene. Int J Biochem Cell Biol. 2010 Mar;42(3):465-71
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7516325
Gene symbol: Sox8
Gene name: SRY (sex determining region Y)-box 8
Reporter: lacZ
Direct Detection
Results
Specimen 2A: embryonic day 10.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS17: cranial ganglion Present 2A
TS17: dorsal root ganglion Present 2A
TS17: future spinal cord Present 2A
TS17: otocyst Present Regionally restricted 2A Expression in part of otic vesicle.
TS17: peripheral nervous system Present Regionally restricted 2A Expression in peripheral nerves.
TS17: hindbrain Weak 2A
TS17: 1st branchial arch Present 2A
TS17: face mesenchyme Present 2A
TS17: forelimb bud Present 2A
TS17: hindlimb bud Present 2A
TS17: migrating neural crest Present Regionally restricted 2A Expression in streams of neural crest cells migrating towards heart and along gut, likely representing cardiac and enteric neural crest cells.
TS17: forebrain-midbrain boundary region Present Regionally restricted 2A Stripe of expression marking boundary of midbrain and forebrain.

Specimen 2E: embryonic day 12.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS20: peripheral nervous system Strong 2E
TS20: trunk mesenchyme Strong Regionally restricted 2E Prominent expression in various mesodermal derivatives in trunk region.

Specimen 3A: embryonic day 10.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS17: future spinal cord Weak Regionally restricted 3A Relatively low expression in spinal cord restricted to stripe in ventral region.
TS17: cranial ganglion Present 3A
TS17: otocyst Present 3A
TS17: trigeminal ganglion Present 3A

Specimen 3E: embryonic day 10.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS17: future spinal cord Weak Regionally restricted 3E Relatively low expression in spinal cord restricted to stripe in ventral region.
TS17: dorsal root ganglion Present 3E
TS17: 1st branchial arch Present 3E
TS17: face mesenchyme Present 3E

Specimen 3I: embryonic day 10.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS17: future spinal cord Weak Regionally restricted 3I Relatively low expression in spinal cord restricted to stripe in ventral region.
TS17: dorsal root ganglion Present 3I
TS17: sympathetic nervous system Present Regionally restricted 3I Expression in sympathetic ganglia.
TS17: migrating neural crest Present Regionally restricted 3I Expression in streams of neural crest cells migrating towards heart and along gut, likely representing cardiac and enteric neural crest cells.
TS17: limb mesenchyme Present Ubiquitous 3I Uniform expression in limb bud mesenchyme.

Specimen 4A: embryonic day 10.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 4A Domain of expression within ventral spinal cord.
TS17: dorsal root ganglion Present 4A
TS17: peripheral nervous system Present Regionally restricted 4A Expression in peripheral nerve.

Specimen 4E: embryonic day 10.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS17: sympathetic nervous system Present Regionally restricted 4E Expression in sympathetic ganglia.
TS17: peripheral nervous system Present Regionally restricted 4E Expression in peripheral nerve.
TS17: limb bud Present 4E
TS17: migrating neural crest Present Regionally restricted 4E Expression in streams of neural crest cells migrating towards heart and along gut, likely representing cardiac and enteric neural crest cells.

Specimen 4I: embryonic day 12.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS20: extrinsic ocular pre-muscle mass Present 4I Expression in eyes including retina, posterior part of lens and various eye muscles.
TS20: lens primordium Present 4I Expression in eyes including retina, posterior part of lens and various eye muscles.
TS20: retina Present 4I Expression in eyes including retina, posterior part of lens and various eye muscles.

Specimen 5A: embryonic day 12.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS20: peripheral nervous system Strong 5A
TS20: skeletal muscle Strong 5A Strong expression in many muscles throughout body.

Specimen 5D: embryonic day 12.5; Sox8tm1Weg/Sox8+ (more )
Structure Level Pattern Image Note
TS20: limb cartilage condensation Present 5D Non-uniform expression marking developing muscles, chondrogenic condensations and interdigital regions of forelimb and hindlimb.
TS20: limb interdigital region Present 5D Non-uniform expression marking developing muscles, chondrogenic condensations and interdigital regions of forelimb and hindlimb.
TS20: limb musculature Present 5D Non-uniform expression marking developing muscles, chondrogenic condensations and interdigital regions of forelimb and hindlimb.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory