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Gene Expression Data
Assay Details
Assay
Reference: J:281257 Witteveen JS, et al., Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. Nat Genet. 2016 Aug;48(8):877-87
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7514844
Gene symbol: Sin3a
Gene name: transcriptional regulator, SIN3A (yeast)
Antibody: anti-Sin3A (ab3479)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2d: embryonic day 14.5 (more )
Note: Double labeled: green - Sin3a; red - Bcl11b (assay MGI:7514845).
Structure Level Pattern Image Note
TS22: neocortex Moderate Regionally restricted 2d Expression is in the prefrontal cortex.
TS22: brain Present Regionally restricted 2d Expression is in various brain regions.

Specimen 2e: embryonic day 14.5 (more )
Note: Double labeled: green - Sin3a; red - Bcl11b (assay MGI:7514845).
Structure Level Pattern Image Note
TS22: neocortex Moderate Regionally restricted 2e Expression is in the somatosensory cortex.
TS22: brain Present Regionally restricted 2e Expression is in various brain regions.

Specimen 2g: embryonic day 16.5 (more )
Note: Double labeled: green - Sin3a; red - Bcl11b (assay MGI:7514845).
Structure Level Pattern Image Note
TS24: neocortex region Strong Regionally restricted 2g Expression is in the somatosensory cortex in the proliferative zone.
TS24: cerebral cortex intermediate zone Moderate 2g
TS24: cortical plate Moderate 2g

Specimen 2h: embryonic day 18.5 (more )
Note: Double labeled: green - Sin3a; red - Bcl11b (assay MGI:7514845).
Structure Level Pattern Image Note
TS26: parietal cortex Strong Regionally restricted 2h Expression is in the somatosensory cortex in the proliferative zone.
TS26: cerebral cortex intermediate zone Moderate 2h
TS26: cortical plate Moderate 2h

Specimen 2i: postnatal day 7 (more )
Note: Double labeled: green - Sin3a; red - Bcl11b (assay MGI:7514845).
Structure Level Pattern Image Note
TS28: somatosensory cortex Strong 2i
TS28: neocortex layer Moderate Regionally restricted 2i Expression is in the intermediate zone and the cortical plate.

Specimen 2j: postnatal day 23 (more )
Note: Double labeled: green - Sin3a; red - Bcl11b (assay MGI:7514845).
Structure Level Pattern Image Note
TS28: somatosensory cortex Strong 2j
TS28: neocortex layer Moderate Regionally restricted 2j Expression is in the intermediate zone and the cortical plate.

Specimen S3a E14.5: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex subventricular zone Present Regionally restricted S3a E14.5 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS22: cerebral cortex ventricular layer Present Regionally restricted S3a E14.5 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS22: cerebral cortex intermediate zone neuron Present Regionally restricted S3a E14.5 Expression is in newborn neurons.
TS22: cortical plate neuron Present Regionally restricted S3a E14.5 Expression is in newborn neurons.
TS22: cerebral cortex Present S3a E14.5

Specimen S3a E16.5: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: cerebral cortex subventricular zone Present Regionally restricted S3a E16.5 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS24: cerebral cortex ventricular layer Present Regionally restricted S3a E16.5 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS24: cerebral cortex intermediate zone neuron Present Regionally restricted S3a E16.5 Expression is in newborn neurons.
TS24: cortical plate neuron Present Regionally restricted S3a E16.5 Expression is in newborn neurons.
TS24: cerebral cortex Present S3a E16.5

Specimen S3a E18.5: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex subventricular zone Present Regionally restricted S3a E18.5 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS26: cerebral cortex ventricular zone Present Regionally restricted S3a E18.5 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS26: cerebral cortex intermediate zone neuron Present Regionally restricted S3a E18.5 Expression is in newborn neurons.
TS26: cortical plate neuron Present Regionally restricted S3a E18.5 Expression is in newborn neurons.
TS26: cerebral cortex Present S3a E18.5

Specimen S3a P7: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present Regionally restricted S3a P7 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS28: cerebral cortex ventricular zone Present Regionally restricted S3a P7 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS28: cerebral cortex neuron Present Regionally restricted S3a P7 Expression is in newborn neurons.

Specimen S3a P14: postnatal day 14 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present Regionally restricted S3a P14 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS28: cerebral cortex ventricular zone Present Regionally restricted S3a P14 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS28: cerebral cortex neuron Present Regionally restricted S3a P14 Expression is in newborn neurons.

Specimen S3a P21: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present Regionally restricted S3a P21 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS28: cerebral cortex ventricular zone Present Regionally restricted S3a P21 Expression is in the nucleus in apical progenitors in the proliferative zone.
TS28: cerebral cortex neuron Present Regionally restricted S3a P21 Expression is in newborn neurons.

Specimen S3b E14.5: embryonic day 14.5 (more )
Note: Double labeled: green - Sin3a; red - Mki67 (assay MGI:7514850).
Structure Level Pattern Image Note
TS22: neocortex Present S3b E14.5 Expression is in actively dividing cells in the proliferative zone in the somatosensory cortical area.

Specimen S3b E16.5: embryonic day 16.5 (more )
Note: Double labeled: green - Sin3a; red - Mki67 (assay MGI:7514850).
Structure Level Pattern Image Note
TS24: neocortex region Present Regionally restricted S3b E16.5 Expression is in actively dividing cells in the proliferative zone in the somatosensory cortical area.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory