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Gene Expression Data
Assay Details
Assay
Reference: J:238698 Kasparek P, et al., KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS Genet. 2017 Jan;13(1):e1006566
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7484324
Gene symbol: Cdsn
Gene name: corneodesmosin
Antibody: anti-CDSN
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen S8 CDSN wt: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: hair inner root sheath Present S8_CDSN wt
TS28: hair follicle Present Regionally restricted S8_CDSN wt No expression in hyperkeratotic follicles.
TS28: epidermis granular layer Present Regionally restricted S8_CDSN wt Expression in upper granular layer.
TS28: epidermis Present Regionally restricted S8_CDSN wt No expression in statum granulosum/stratum corneum interface
Specimen S8 CDSN Klk5-/-;A135X/A135X: postnatal day 5; Klk5tm1Rase/Klk5tm1Rase, Spink5em1Rase/Spink5em1Rase (more )
Structure Level Pattern Image Note
TS28: hair inner root sheath Present S8_CDSN Klk5-/-;A135X/A135X Expression only in inner root sheath of non-hyperplastic hair follicles.
TS28: hair follicle Present Regionally restricted S8_CDSN Klk5-/-;A135X/A135X No expression in hyperkeratotic follicles.
TS28: epidermis Present Regionally restricted S8_CDSN Klk5-/-;A135X/A135X No expression in statum granulosum/stratum corneum interface
Specimen S8 CDSN Klk5-/-;Klk7-/-;A135X/A135X: postnatal day 5; Klk5tm1Rase/Klk5tm1Rase, Klk7em1Rase/Klk7em1Rase, Spink5em1Rase/Spink5em1Rase (more )
Structure Level Pattern Image Note
TS28: hair inner root sheath Present S8_CDSN Klk5-/-;Klk7-/-;A135X/A135X
TS28: hair follicle Present Regionally restricted S8_CDSN Klk5-/-;Klk7-/-;A135X/A135X No expression in hyperkeratotic follicles.
TS28: epidermis granular layer Present Regionally restricted S8_CDSN Klk5-/-;Klk7-/-;A135X/A135X Expression in upper granular layer.
TS28: epidermis Present Regionally restricted S8_CDSN Klk5-/-;Klk7-/-;A135X/A135X No expression in statum granulosum/stratum corneum interface
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory