Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:126484
Luo W, et al., A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007 Jun 7;54(5):739-54
|
|
Assay type:
|
RNA in situ
|
|
MGI Accession ID:
|
MGI:7481267
|
|
Gene symbol:
|
Ret
|
|
Gene name:
|
ret proto-oncogene
|
|
Probe:
|
Ret probe
|
|
Probe preparation:
|
labelled with digoxigenin RNA
|
|
|
Results
|
Specimen
2A:
(close  )
|
Genetic Background:
|
involves: 129S7/SvEvBrd * 129X1/SvJ
|
|
Mutant Allele(s):
|
Baxtm1Sjk/Baxtm1Sjk
Ngftm1Gne/Ngf+
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: dorsal root ganglion |
sensory neuron of dorsal root ganglion |
Present |
Regionally restricted |
2A
|
Expression in 62.4% of neurons.
|
Specimen
2B:
(close )
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: dorsal root ganglion |
sensory neuron of dorsal root ganglion |
Weak |
Regionally restricted |
2B
|
Expression dramatically reduced. Number of expressing neurons reduced to 30.5%. Only a few expressing neurons of normal soma size.
|
Specimen
3A:
(close )
|
Genetic Background:
|
involves: 129 * C57BL/6
|
|
Mutant Allele(s):
|
Rettm1Ddg/Rettm1Ddg
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
Specimen
3B:
(close )
|
Genetic Background:
|
involves: 129 * C57BL/6 * C57BL/6J * CBA/J
|
|
Mutant Allele(s):
|
Rettm1Ddg/Rettm1Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Note:
|
Conditional mutant.
|
Specimen
S3C:
(close )
|
Genetic Background:
|
involves: 129 * C57BL/6
|
|
Mutant Allele(s):
|
Rettm1Ddg/Rettm1Ddg
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: intestine wall |
enteric neuron |
Present |
|
S3C
|
Expression in enteric neurons in intestinal wall.
|
Specimen
S3D:
(close )
|
Genetic Background:
|
involves: 129 * C57BL/6 * C57BL/6J * CBA/J
|
|
Mutant Allele(s):
|
Rettm1Ddg/Rettm1Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Note:
|
Conditional mutant.
|
| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: intestine wall |
enteric neuron |
Absent |
|
S3D
|
Lack of enteric neurons in intestinal wall.
|
Specimen
Ret f/f/ not shown:
(close )
|
Genetic Background:
|
involves: 129 * C57BL/6
|
|
Mutant Allele(s):
|
Rettm1Ddg/Rettm1Ddg
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
Specimen
Ret f/f/;Wnt1-Cre not shown:
(close )
|
Genetic Background:
|
involves: 129 * C57BL/6 * C57BL/6J * CBA/J
|
|
Mutant Allele(s):
|
Rettm1Ddg/Rettm1Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Note:
|
Conditional mutant.
|
|
)
Analysis Tools