About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:299026 Kannan-Sundhari A, et al., Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival. Front Cell Dev Biol. 2020;8:576654
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7470855
Gene symbol: Brd4
Gene name: bromodomain containing 4
Results
Specimen 1B: postnatal day 0 (more )
Note: Double labeled: green - Brd4; red - Myo7a (assay MGI:7470859).
Structure Cell Type Level Pattern Image Note
TS27: inner ear Present Ubiquitous 1B Brd4 , 1B Merge Expression is in the nucleus of every cell-type.
TS27: inner ear cochlea auditory hair cell Present 1B Brd4 , 1B Merge
Specimen 1E control: postnatal day 8 (more )
Note: Double labeled: green - Brd4; red - Myo7a (assay MGI:7470859).
Structure Cell Type Level Pattern Image Note
TS28: cochlea cochlear inner hair cell Present 1E +/+ Brd4 , 1E +/+ Merge Expression includes inner and outer hair cells.
TS28: cochlea cochlear outer hair cell Present 1E +/+ Brd4 , 1E +/+ Merge Expression includes inner and outer hair cells.
Specimen 1E: postnatal day 8; Brd4tm1c(EUCOMM)Wtsi/Brd4tm1c(EUCOMM)Wtsi, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Double labeled: green - Brd4; red - Myo7a (assay MGI:7470859).
Structure Cell Type Level Pattern Image Note
TS28: inner ear Present Regionally restricted 1E -/- Brd4 , 1E -/- Merge Expression is absent in inner and outer hair cells.
TS28: inner ear cochlear inner hair cell Absent 1E -/- Brd4 , 1E -/- Merge
TS28: inner ear cochlear outer hair cell Absent 1E -/- Brd4 , 1E -/- Merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory