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Gene Expression Data
Assay Details
Assay
Reference: J:299026 Kannan-Sundhari A, et al., Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival. Front Cell Dev Biol. 2020;8:576654
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7470855
Gene symbol: Brd4
Gene name: bromodomain containing 4
Results
Specimen 1B: postnatal day 0 (more )
Note: Double labeled: green - Brd4; red - Myo7a (assay MGI:7470859).
Structure Cell Type Level Pattern Image Note
TS27: inner ear Present Ubiquitous 1B Brd4 , 1B Merge Expression is in the nucleus of every cell-type.
TS27: inner ear cochlea auditory hair cell Present 1B Brd4 , 1B Merge
Specimen 1E control: postnatal day 8 (more )
Note: Double labeled: green - Brd4; red - Myo7a (assay MGI:7470859).
Structure Cell Type Level Pattern Image Note
TS28: cochlea cochlear inner hair cell Present 1E +/+ Brd4 , 1E +/+ Merge Expression includes inner and outer hair cells.
TS28: cochlea cochlear outer hair cell Present 1E +/+ Brd4 , 1E +/+ Merge Expression includes inner and outer hair cells.
Specimen 1E: postnatal day 8; Brd4tm1c(EUCOMM)Wtsi/Brd4tm1c(EUCOMM)Wtsi, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Double labeled: green - Brd4; red - Myo7a (assay MGI:7470859).
Structure Cell Type Level Pattern Image Note
TS28: inner ear Present Regionally restricted 1E -/- Brd4 , 1E -/- Merge Expression is absent in inner and outer hair cells.
TS28: inner ear cochlear inner hair cell Absent 1E -/- Brd4 , 1E -/- Merge
TS28: inner ear cochlear outer hair cell Absent 1E -/- Brd4 , 1E -/- Merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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