Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Igkv3-5*-MYC)DLoxP5Plbe
Name:	transgene insertion DLoxP5, P Leif Bergsagel
MGI ID:	MGI:7430789
Synonyms:	Vk*MYCDLoxP
Transgene:	Tg(Igkv3-5*-MYC)DLoxP5Plbe  Location: unknown  Genetic Position: Chr1, Syntenic
Alliance:	Tg(Igkv3-5*-MYC)DLoxP5Plbe page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Igkv3-5*-MYC)DLoxP5Plbe expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human MYC (4609) Bmyc  (MGI:88184) Myc  (MGI:97250)   Mutation details: The mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector OQ428542). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. This vector lacks the loxP site found in Tg(Igkv3-5*-MYC)24Plbe. In line 5 the transgene inserted at chr1:180288300-180308245. (J:131912)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:131912 Chesi M, et al., AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008 Feb;13(2):167-80
All:	1 reference(s)