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Gene Expression Data
Assay Details
Assay
Reference: J:329966 Bell CJ, et al., Borcs6 is required for endo-lysosomal degradation during early development. Mol Reprod Dev. 2022 Aug;89(8):337-350
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7398486
Gene symbol: Lamp1
Gene name: lysosomal-associated membrane protein 1
Antibody: anti-Lamp1 [1D4B] (ab25245)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 4a/c''/c''': embryonic day 6.5 (more )
Note: Triple labeled: white - Lamp1; green - E-cadherin (Cdh1 assay MGI:7398481); red - Rab7 (assay MGI:7398485).
Structure Level Pattern Image Note
TS9: primitive endoderm Weak Widespread 4c''' , 4c'' , 4a Expression on surface of endosomes. Faint expression throughout all cells.
Specimen 4b/d''/d''': embryonic day 6.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6tm1.1(KOMP)Vlcg (more )
Note: Triple labeled: white - Lamp1; green - E-cadherin (Cdh1 assay MGI:7398481); red - Rab7 (assay MGI:7398485).
Structure Level Pattern Image Note
TS9: primitive endoderm Present Regionally restricted 4b , 4d'' , 4d''' Stronger expression than in control embryo, often with many grouped foci.
Specimen 4e/e'''/g: embryonic day 6.5 (more )
Note: Double labeled: white - Lamp1; red - Rab7 (assay MGI:7398485).
Structure Level Pattern Image Note
TS9: primitive endoderm Present Regionally restricted 4g , 4e , 4e''' Higher levels of expression in proximal half of visceral endoderm thatn in distal half.
Specimen 4f/f'''/h: embryonic day 6.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Note: Double labeled: white - Lamp1; red - Rab7 (assay MGI:7398485).
Structure Level Pattern Image Note
TS9: primitive endoderm Present Regionally restricted 4f , 4h , 4f''' Late endosomes dispersed evenly throughout visceral endoderm with no difference between proximal and distal parts. Large discrete patches non-overlapping with Rab7 expression.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory