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Gene Expression Data
Assay Details
Assay
Reference: J:331477 Bhalla P, et al., Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome. J Clin Invest. 2022 Nov 15;132(22)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7398222
Gene symbol: Krt8
Gene name: keratin 8
Results
Specimen 1B Krt8 +/+: embryonic day 18.0-18.5 (more )
Note: Double labeled: red - Krt8; green - Krt14 (assay MGI:7398223).
Structure Cell Type Level Pattern Image Note
TS26: thymus cortical thymic epithelial cell Present 1B +/+ (middle)
TS26: thymus epithelial cell of thymus Present Regionally restricted 1B +/+ (middle) Coexpression with Krt14 in immature thymic epithelial cells.
Specimen 1B Krt8 +/neo2: embryonic day 18.0-18.5; Tbx1tm5Bld/Tbx1+ (more )
Note: Double labeled: red - Krt8; green - Krt14 (assay MGI:7398223).
Structure Cell Type Level Pattern Image Note
TS26: thymus cortical thymic epithelial cell Present 1B +/neo2 (middle)
TS26: thymus epithelial cell of thymus Present Regionally restricted 1B +/neo2 (middle) Coexpression with Krt14 in immature thymic epithelial cells.
Specimen 1B Krt8 neo2/neo2 e.g.3: embryonic day 18.0-18.5; Tbx1tm5Bld/Tbx1tm5Bld (more )
Note: Double labeled: red - Krt8; green - Krt14 (assay MGI:7398223).
Structure Cell Type Level Pattern Image Note
TS26: thymus cortical thymic epithelial cell Present 1B neo2/neo2 e.g.3 (middle) Authors report normal thymic epithelial cell composition in homozygous embryos.
TS26: thymus epithelial cell of thymus Present Regionally restricted 1B neo2/neo2 e.g.3 (middle) Coexpression with Krt14 in immature thymic epithelial cells.
Specimen 1B Krt8 neo2/neo2 e.g.4: embryonic day 18.0-18.5; Tbx1tm5Bld/Tbx1tm5Bld (more )
Note: Double labeled: red - Krt8; green - Krt14 (assay MGI:7398223).
Structure Cell Type Level Pattern Image Note
TS26: thymus cortical thymic epithelial cell Present 1B neo2/neo2 e.g.4 (middle) Authors report normal thymic epithelial cell composition in homozygous embryos.
TS26: thymus epithelial cell of thymus Present Regionally restricted 1B neo2/neo2 e.g.4 (middle) Coexpression with Krt14 in immature thymic epithelial cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory