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Gene Expression Data
Assay Details
Assay
Reference: J:309372 Padgett LR, et al., Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development. FASEB J. 2021 May;35(5):e21473
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7329925
Gene symbol: Ins1
Gene name: insulin I
Antibody: anti-insulin
Detection system: Secondary antibody
Results
Specimen 2B Ptf1a-cre: postnatal week 5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Triple labeled: red - Ins1 and Ins2; green - Gcg (assay MGI:7329928); blue - Cpa1 (assay MGI:7329929).
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present 2B Ptr1a-cre
Specimen 2B Dhps PANC (left): postnatal week 5; Dhpstm1.1Mirm/Dhpstm1.1Mirm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Triple labeled: red - Ins1 and Ins2; green - Gcg (assay MGI:7329928); blue - Cpa1 (assay MGI:7329929).
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present 2B Dhps deltaPANC (left) Expression in islets in pancreatic remnant.
Specimen 2B Dhps PANC (right): postnatal week 5; Dhpstm1.1Mirm/Dhpstm1.1Mirm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Triple labeled: red - Ins1 and Ins2; green - Gcg (assay MGI:7329928); blue - Cpa1 (assay MGI:7329929).
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present 2B Dhps deltaPANC (right) Expression in islets in pancreatic remnant.
Specimen 3C: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: green - Ins1 and Ins2; red - Cpa1 (assay MGI:7329929).
Structure Cell Type Level Pattern Image Note
TS22: pancreas progenitor cell of endocrine pancreas Present 3C
Specimen 3D: embryonic day 14.5; Dhpstm1.1Mirm/Dhpstm1.1Mirm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: green - Ins1 and Ins2; red - Cpa1 (assay MGI:7329929).
Structure Cell Type Level Pattern Image Note
TS22: pancreas progenitor cell of endocrine pancreas Present 3D
Specimen 4D: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: pancreas progenitor cell of endocrine pancreas Present 4D
Specimen 4E: embryonic day 14.5; Eif5atm1.1Tlm/Eif5atm1.1Tlm, Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: pancreas progenitor cell of endocrine pancreas Present 4E No significant difference in endocrine cell number from that of controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory