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Gene Expression Data
Assay Details
Assay
Reference: J:252376 Baker ZN, et al., The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Hum Mol Genet. 2017 Dec 1;26(23):4617-4628
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7284150
Gene symbol: Slc31a1
Gene name: solute carrier family 31, member 1
Antibody: CTR1 antibody
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5A Control CTR1: postnatal day 60 (more )
Note: Double labeled: green - CTR1 (Slc31a1); red - Na+/K+ ATPase.
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted 5A Control CTR1 , 5A Control Overlay Expression primarily localized to plasma membrane; intense expression at intercalated discs
Specimen 5A Sco1stm/stm CTR1: postnatal day 60; Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi, Tg(Ckmm-cre)5Khn/0 (more )
Note: Conditional mutant. Double labeled: green - CTR1 (Slc31a1); red - Na+/K+ ATPase.
Structure Level Pattern Image Note
TS28: heart Present Diffuse 5A Sco1stm/stm1 Overlay , 5A Sco1stm/stm CTR1 Expression more diffuse and less coincident with Na+/K+ ATPase expression.
Specimen 6C Control CTR1: postnatal day 120 (more )
Note: Double labeled: green - CTR1 (Slc31a1); red - Na+/K+ ATPase.
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted 6C Control CTR1 , 6C Control Overlay Expression at plasma membrane and intercalated discs.
Specimen 6C Sco1G115S/G115S CTR1: postnatal day 120; Sco1em1Scly/Sco1em1Scly (more )
Note: Double labeled: green - CTR1 (Slc31a1); red - Na+/K+ ATPase.
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted 6C Sco1G115S/G115S Overlay , 6C Sco1G115S/G115S CTR1 Expression predominantly in cytoplasm.
Specimen S3A Control CTR1: postnatal day 60 (more )
Note: Double labeled: green - CTR1 (Slc31a1); red - Rab5a (assay MGI:7284151).
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted S3A Control Overlay , S3A Control CTR1
Specimen S3A Sco1stm/stm CTR1: postnatal day 60; Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi, Tg(Ckmm-cre)5Khn/0 (more )
Note: Conditional mutant. Double labeled: green - CTR1 (Slc31a1); red - Rab5a (assay MGI:7284151).
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted S3A Sco1stmstm CTR1 , S3A Sco2stm/stm Overlay Expression co-localized with Rab5.
Specimen S3B Control CTR1: postnatal day 60 (more )
Note: Triple labeled: green - CTR1 (Slc31a1); red - Eea1 (assay MGI:7284152); red - Lamp1 (assay MGI:7284153).
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted S3B Control Overlay , S3B Control CTR1
Specimen S3B Sco1stm/stm CTR1: postnatal day 60; Sco1tm1c(KOMP)Wtsi/Sco1tm1c(KOMP)Wtsi, Tg(Ckmm-cre)5Khn/0 (more )
Note: Conditional mutant. Triple labeled: green - CTR1 (Slc31a1); red - Eea1 (assay MGI:7284152); red - Lamp1 (assay MGI:7284153).
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted S3B Sco1stm/stm Overlay , S3B Sco1stm/stm CTR1 No co-localization of expression with Eea1 or Lamp1.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory