Gene Expression Data
Assay Details
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Assay
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Reference:
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J:208287
Haller JF, et al., Endogenous beta-glucocerebrosidase activity in Abca12(-)/(-)epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. J Lipid Res. 2014 Mar;55(3):493-503
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:7281794
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Gene symbol:
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Gba1
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Gene name:
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glucosylceramidase beta 1
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Results
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Specimen
5C +/+:
embryonic day 18.5
(more  )
Specimen
5C +/+:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: epidermis |
Present |
Regionally restricted |
5C +/+
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Expression in nucleated cellular layers in a cytoplasmic distribution.
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| TS26: epidermis cornified layer |
Present |
Regionally restricted |
5C +/+
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Expression in stratum corneum localized to interstitial spaces.
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Specimen
5C -/-:
(close )
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Genetic Background:
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involves: 129S/SvEvBrd * C57BL/6J
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Mutant Allele(s):
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Abca12tm1Lex/Abca12tm1Lex
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: epidermis |
Strong |
Regionally restricted |
5C -/-
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Expression markedly increased in whole skin, particularly in upper stratum corneum.
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| TS26: epidermis cornified layer |
Very strong |
Regionally restricted |
5C -/-
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Expression in hyperkeratotic stratum corneum maintained a largely interstitial distribution.
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