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Gene Expression Data
Assay Details
Assay
Reference: J:158688 Seshadri S, et al., Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5622-7
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6861788
Gene symbol: Disc1
Gene name: disrupted in schizophrenia 1
Antibody: anti-mExon3
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 3D BACE1-/-: postnatal day 0; Bace1tm1Pcw/Bace1tm1Pcw (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Weak 3D BACE1-/- bottom , 3D BASE1-/- top Expression in cell bodies and nuclei is similar to wild-type but there is a 76.4% reduction in expression in neurites in this mutant compared to wild-type.
Specimen 3D WT: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present 3D WT bottom , 3D WT top
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory