Sox10 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:47640 Herbarth B, et al., Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5161-5
Assay type:	RNA in situ
MGI Accession ID:	MGI:6842952
Gene symbol:	Sox10
Gene name:	SRY (sex determining region Y)-box 10

Probe:	Sox10 probe30
Probe preparation:	Antisense labelled with digoxigenin RNA

Results

Specimen 3b Dom/Dom lateral: embryonic day 10.5; Sox10^Dom/Sox10^Dom (more

)

Structure	Level	Image	Note
TS17: cranial ganglion	Absent	3b Dom/Dom lateral	Loss of expression in all cranial ganglia and nerves.
TS17: cranial nerve	Absent	3b Dom/Dom lateral	Loss of expression in all cranial ganglia and nerves.
TS17: dorsal root ganglion	Present	3b Dom/Dom lateral	Expression in trunk neural crest-derived dorsal root ganglia.

Specimen 3b Dom/Dom dorsal: embryonic day 10.5; Sox10^Dom/Sox10^Dom (more

)

Structure	Level	Image	Note
TS17: cranial ganglion	Absent	3b Dom/Dom dorsal	Loss of expression in all cranial ganglia and nerves.
TS17: cranial nerve	Absent	3b Dom/Dom dorsal	Loss of expression in all cranial ganglia and nerves.
TS17: dorsal root ganglion	Present	3b Dom/Dom dorsal	Expression in trunk neural crest-derived dorsal root ganglia.

Specimen 3b Dom/+ lateral: embryonic day 10.5; Sox10^Dom/Sox10⁺ (more

)

Structure	Level	Image	Note
TS17: facio-acoustic ganglion complex	Weak	3b Dom/+ lateral	Overall reduction of expression in heterozygous mice. No qualitative difference in expression between hterozygous and wild-type mice.
TS17: trigeminal ganglion	Weak	3b Dom/+ lateral	Overall reduction of expression in heterozygous mice. No qualitative difference in expression between hterozygous and wild-type mice.
TS17: vagus ganglion	Weak	3b Dom/+ lateral	Overall reduction of expression in heterozygous mice. No qualitative difference in expression between hterozygous and wild-type mice.
TS17: dorsal root ganglion	Present	3b Dom/+ lateral	Expression in trunk neural crest-derived dorsal root ganglia.

Specimen 3b Dom/+ dorsal: embryonic day 10.5; Sox10^Dom/Sox10⁺ (more

)

Structure	Level	Image	Note
TS17: facio-acoustic ganglion complex	Weak	3b Dom/+ dorsal	Overall reduction of expression in heterozygous mice. No qualitative difference in expression between hterozygous and wild-type mice.
TS17: trigeminal ganglion	Weak	3b Dom/+ dorsal	Overall reduction of expression in heterozygous mice. No qualitative difference in expression between hterozygous and wild-type mice.
TS17: vagus ganglion	Weak	3b Dom/+ dorsal	Overall reduction of expression in heterozygous mice. No qualitative difference in expression between hterozygous and wild-type mice.
TS17: dorsal root ganglion	Present	3b Dom/+ dorsal	Expression in trunk neural crest-derived dorsal root ganglia.

Specimen 3b +/+ lateral: embryonic day 10.5 (more

)

Structure	Level	Image	Note
TS17: facio-acoustic ganglion complex	Present	3b +/+ lateral
TS17: trigeminal ganglion	Present	3b +/+ lateral
TS17: vagus ganglion	Present	3b +/+ lateral
TS17: dorsal root ganglion	Present	3b +/+ lateral	Expression in trunk neural crest-derived dorsal root ganglia.

Specimen 3b +/+ dorsal: embryonic day 10.5 (more

)

Structure	Level	Image	Note
TS17: facio-acoustic ganglion complex	Present	3b +/+ dorsal
TS17: trigeminal ganglion	Present	3b +/+ dorsal
TS17: vagus ganglion	Present	3b +/+ dorsal
TS17: dorsal root ganglion	Present	3b +/+ dorsal	Expression in trunk neural crest-derived dorsal root ganglia.

Specimen 3c Sox10 Dom/Dom left: embryonic day 10.5; Sox10^Dom/Sox10^Dom (more

)

Structure	Level	Pattern	Image	Note
TS17: cranial nerve	Absent		3c Sox10 Dom/Dom left

Specimen 3c Sox10 +/+ left: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: cranial nerve	Present		3c Sox10 +/+ left

Specimen 3c Som10 Dom/Dom right: embryonic day 10.5; Sox10^Dom/Sox10^Dom (more

)

Structure	Level	Pattern	Image	Note
TS17: dorsal root ganglion	Present		3c Sox10 Dom/Dom right	Expression in trunk neural crest-derived dorsal root ganglia.
TS17: spinal nerve	Weak		3c Sox10 Dom/Dom right	Substantial reduction in intensity of expression along motor nerves.

Specimen 3c Sox10 +/+ right: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: dorsal root ganglion	Present		3c Sox10 +/+ right	Expression in trunk neural crest-derived dorsal root ganglia
TS17: spinal nerve	Present		3c Sox10 +/+ right	Expression in motor nerves.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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