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Gene Expression Data
Assay Details
Assay
Reference: J:217191 Zhang Y, et al., Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis. Dev Biol. 2014 Dec 1;396(1):19-30
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6763229
Gene symbol: Mdm2
Gene name: transformed mouse 3T3 cell double minute 2
Antibody: anti-MDM2 (SMP14)
Detection system: Secondary antibody
Results
Specimen 7A MDM2 Control: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+ , Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS16: lens pit Present 7A MDM2 Control
Specimen 7A MDM2 LE; M2 f/f; p53 f/f: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2tm2.1Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: lens pit Absent 7A MDM2 LE; M2 f/f; p53 f/f
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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