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Gene Expression Data
Assay Details
Assay
Reference: J:184285 Wang PS, et al., Loss of protein-tyrosine phosphatase alpha (PTPalpha) increases proliferation and delays maturation of oligodendrocyte progenitor cells. J Biol Chem. 2012 Apr 6;287(15):12529-40
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6690648
Gene symbol: Apc
Gene name: APC, WNT signaling pathway regulator
Antibody: Anti-CC1
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 9B WT P10: postnatal day 10 (more )
Note: Double labeled: green - Apc; red - Cspg4 (assay MGI:6690646).
Structure Level Pattern Image Note
TS28: corpus callosum Present 9B WT P10 Expression was detected in mature oligodendrocytes. At P10, the oligodendrocyte lineage population in the corpus callosum was composed of 55.3% Apc-positive cells.
Specimen 9B PTPalpha-/- P10: postnatal day 10; Ptpratm1Cjp/Ptpratm1Cjp (more )
Note: Double labeled: green - Apc; red - Cspg4 (assay MGI:6690646).
Structure Level Pattern Image Note
TS28: corpus callosum Present 9B PTPalpha-/- P10 Expression was detected in mature oligodendrocytes. At P10, the oligodendrocyte lineage population in the PTPalpha-/- corpus callosum was composed of 37% Apc-positive cells.
Specimen 9B WT P18: postnatal day 18 (more )
Note: Double labeled: green - Apc; red - Cspg4 (assay MGI:6690646).
Structure Level Pattern Image Note
TS28: corpus callosum Present 9B WT P18 Expression was detected in mature oligodendrocytes. At P18, the oligodendrocyte lineage population in the corpus callosum was composed of 76.1% Apc-positive cells.
Specimen 9B PTPalpha-/- P18: postnatal day 18; Ptpratm1Cjp/Ptpratm1Cjp (more )
Note: Double labeled: green - Apc; red - Cspg4 (assay MGI:6690646).
Structure Level Pattern Image Note
TS28: corpus callosum Present 9B PTPalpha-/- P18 Expression was detected in mature oligodendrocytes. At P18, the oligodendrocyte lineage population in the PTPalpha-/- corpus callosum was composed of 66.7% Apc-positive cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory