Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Abi3em1Aduci
Name:	ABI family member 3; endonuclease-mediated mutation 1, Frank LaFerla
MGI ID:	MGI:6508549
Synonyms:	Abi3*S209F
Gene:	Abi3  Location: Chr11:95720900-95733302 bp, - strand  Genetic Position: Chr11, 59.01 cM
Alliance:	Abi3em1Aduci page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Humanized sequence) Mutation:    Insertion of gene trap vector   Mutation details: CRISPR/cas9 genome editing is used to create an TCT to TTC missense mutation resulting in a serine to phenylalanine change (S212F). This mutation (SNP rs616338) is homologous to the human S209F SNP which has been shown to correlate with increased risk of sporadic Alzheimer's disease. One silent DNA mutation was also introduced. (J:101977)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abi3 Mutation:	22 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	1 reference(s)