Disc1 Western blot Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:94923 Schurov IL, et al., Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Mol Psychiatry. 2004 Dec;9(12):1100-10
Assay type:	Western blot
MGI Accession ID:	MGI:6504902
Gene symbol:	Disc1
Gene name:	disrupted in schizophrenia 1

Antibody:

anti-DISC1 (D27)

Results

Image: 5a

	Sample Information		Bands				Other Sample Information
Lane	Age	Structure	105 kDa (a)	100 kDa (b)	75 kDa (c)	71 kDa (d)	Genetic Background	Mutant Allele(s)	Sex
+ve	P adult	TS28: cerebral cortex	Weak	Strong	Present	Strong	Not Specified		Not Specified
E10.5	E10.5	TS17: embryo	Weak	Weak	Present (e)	Weak	Not Specified		Not Specified
E13.5	E13.5	TS21: brain	Weak	Strong (f)	Present	Weak	Not Specified		Not Specified
E15.5	E15.5	TS23: brain	Weak	Weak	Present	Weak	Not Specified		Not Specified
E16.5	E16.5	TS24: brain	Weak	Weak (g)	Present	Weak	Not Specified		Not Specified
E17.5	E17.5	TS25: brain	Weak	Weak	Present	Weak	Not Specified		Not Specified
E18.5	E18.5	TS26: brain	Weak	Weak	Present	Weak	Not Specified		Not Specified
E19.5	E19.5	TS26: brain	Weak	Weak	Present	Weak	Not Specified		Not Specified
E20.5	E20.5	TS26: brain	Weak	Weak	Present	Weak	Not Specified		Not Specified

Notes:
(a) Labeled band 1. Low level of expression at all time points.
(b) Labeled band 2.
(c) Labeled band 3. Expression remains at a similar level throughut prenatal and postnatal development.
(d) Labeled band 4. Authors report lower level of expression during neonatal and early postnatal periods.
(e) Expression already abundant at E10.5.
(f) Two significant peaks of expression; first peak at E13.5,
(g) Expression decreased by E16.5.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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