Prph Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:194894 Couesnon A, et al., CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6477282
Gene symbol:	Prph
Gene name:	peripherin

Antibody:

anti-peripherin

Results

Specimen E13.5 +/- not shown: embryonic day 13.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS21: phrenic nerve	Present

Specimen E13.5 -/- not shown: embryonic day 13.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS21: phrenic nerve	Present	Regionally restricted		No difference in innervation patterns of mutant and control diaphragms.

3A +/- ©

Specimen 3A +/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: phrenic nerve	Present		3A +/-

3A -/- ©

Specimen 3A -/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS23: phrenic nerve	Present		3A -/-	No difference in innervation patterns of mutant and control diaphragms.

3B E15.5 +/- ©

Specimen 3B E15.5 +/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: phrenic nerve	Present		3B E15.5 +/-

3B E15.5 -/- ©

Specimen 3B E15.5 -/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS23: phrenic nerve	Present	Regionally restricted	3B E15.5 -/-	In ventral region, innervation pattern incomplete from E15.5 to E18.5.

3B E16.5 +/- ©

Specimen 3B E16.5 +/-: embryonic day 16.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS24: phrenic nerve	Present		3B E16.5 +/-

3B E16.5 -/- ©

Specimen 3B E16.5 -/-: embryonic day 16.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS24: phrenic nerve	Present	Regionally restricted	3B E16.5 -/-	In ventral region, innervation pattern incomplete from E15.5 to E18.5.

3B E17.5 +/- ©

Specimen 3B E17.5 +/-: embryonic day 17.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: phrenic nerve	Present		3B E17.5 +/-

3B E17.5 -/- ©

Specimen 3B E17.5 -/-: embryonic day 17.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS25: phrenic nerve	Present	Regionally restricted	3B E17.5 -/-	In ventral region, innervation pattern incomplete from E15.5 to E18.5.

3B E18.5 +/- ©

Specimen 3B E18.5 +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: phrenic nerve	Present		3B E18.5 +/-

3B E18.5 -/- ©

Specimen 3B E18.5 -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: phrenic nerve	Present	Regionally restricted	3B E18.5 -/-	In ventral region, innervation pattern incomplete from E15.5 to E18.5.

3C Peripherin +/- ©

Specimen 3C +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: phrenic nerve	Present		3C Peripherin +/-

3C Peripherin -/- ©

Specimen 3C -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: phrenic nerve	Present	Regionally restricted	3C Peripherin -/-	Ventral and dorsal branches do not reach most distal part of diaphragm.

S1A +/- ©

Specimen S1A +/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: phrenic nerve	Present		S1A +/-

S1A -/- ©

Specimen S1A -/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS23: phrenic nerve	Present	Regionally restricted	S1A -/-	Dorsal and ventral branches reach muscle extremities.

S1B +/- ©

Specimen S1B +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: phrenic nerve	Present		S1B +/-

S1B -/- ©

Specimen S1B -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: phrenic nerve	Present	Regionally restricted	S1B -/-	Ventral and dorsal branches do not reach most distal part of diaphragm.

S1C E15/5 +/- ©

Specimen S1C E15.5 +/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: phrenic nerve	Present		S1C E15/5 +/-

S1C E15/5 -/- ©

Specimen S1C E15.5 -/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS23: phrenic nerve	Present	Regionally restricted	S1C E15/5 -/-	In dorsal region, innervation pattern is incomplete from E15.5 to E18.5.

S1C E16.5 +/- ©

Specimen S1C E16.5 +/-: embryonic day 16.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS24: phrenic nerve	Present		S1C E16.5 +/-

S1C E16.5 -/- ©

Specimen S1C E16.5 -/-: embryonic day 16.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS24: phrenic nerve	Present	Regionally restricted	S1C E16.5 -/-	In dorsal region, innervation pattern is incomplete from E15.5 to E18.5.

S1C E17.5 +/- ©

Specimen S1C E17.5 +/-: embryonic day 17.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS25: phrenic nerve	Present		S1C E17.5 +/-

S1C E17.5 -/- ©

Specimen S1C E17.5 -/-: embryonic day 17.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS25: phrenic nerve	Present	Regionally restricted	S1C E17.5 -/-	In dorsal region, innervation pattern is incomplete from E15.5 to E18.5.

S1C E18.5 +/- ©

Specimen S1C E18.5 +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: phrenic nerve	Present		S1C E18.5 +/-

S1C E18.5 -/- ©

Specimen S1C E18.5 -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: phrenic nerve	Present	Regionally restricted	S1C E18.5 -/-	In dorsal region, innervation pattern is incomplete from E15.5 to E18.5.

Specimen intecostal muscle not shown: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: intercostal muscle	Present			Authors report no defects in innervation pattern of intercostal msucles.

5B +/- ©

Specimen 5B +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: cranial muscle	Present		5B +/-

5B -/- ©

Specimen 5B -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: cranial muscle	Present		5B -/-	Innervation pattern of superficial layer of levator auris longus muscle is severely impaired. Dramatic loss of innevation observed.

5C +/- ©

Specimen 5C +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: cranial muscle	Present		5C +/-

5C -/- ©

Specimen 5C -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: cranial muscle	Present	Regionally restricted	5C -/-	Innervation is more affected in the auricularis longus (AAL, fast twitch muscle) than in the auricularis superiorix (AS, slow twitch muscle).

5D +/- ©

Specimen 5D +/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: cranial muscle	Present		5D +/-

5D -/- ©

Specimen 5D -/-: embryonic day 15.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS23: cranial muscle	Present	Regionally restricted	5D -/-	Innervation defects noticeable as early as E15.5.

S2A +/- ©

Specimen S2A +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: tibialis anterior	Present		S2A +/-

S2A -/- ©

Specimen S2A -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: tibialis anterior	Present	Regionally restricted	S2A -/-	Innervation pattern moderately altered.

S2B +/- ©

Specimen S2B +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: extensor digitorum longus	Present		S2B +/-

S2B -/- ©

Specimen S2B -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: extensor digitorum longus	Present	Regionally restricted	S2B -/-	Innervation pattern moderately altered.

S2C +/- ©

Specimen S2C +/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3⁺ (more

)

Structure	Level	Pattern	Image	Note
TS26: soleus	Present		S2C +/-

S2C -/- ©

Specimen S2C -/-: embryonic day 18.5; Clip3^tm1.1Ics/Clip3^tm1.1Ics (more

)

Structure	Level	Pattern	Image	Note
TS26: soleus	Present	Regionally restricted	S2C -/-	Only slight innervation defects.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24