Gene Expression Data
Assay Details
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Assay
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Reference:
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J:288446
Christians A, et al., Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Hum Mol Genet. 2020 May 8;29(7):1192-1204
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:6472987
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Gene symbol:
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Upk3b
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Gene name:
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uroplakin 3B
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Results
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Specimen
1B +/+:
embryonic day 18.5
(more  )
Specimen
1B +/+:
(close  )
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Genetic Background:
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involves: 129S7/SvEvBrd * NMRI
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Paraffin
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Specimen
1B -/-:
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd * NMRI
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Mutant Allele(s):
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Lifrtm1Imx/Lifrtm1Imx
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: superficial cell layer of ureter |
Strong |
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1B middle -/-
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Similar as in the wild-type. A narrowed ureteral lumen and positive cells located in the lumen were seen. The adluminal cell layer showed some discontinuity in the expression of the marker.
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Specimen
2 +/+:
embryonic day 18.5
(more )
Specimen
2 +/+:
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd * NMRI
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Paraffin
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Specimen
2 -/-:
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd * NMRI
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Mutant Allele(s):
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Lifrtm1Imx/Lifrtm1Imx
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: superficial cell layer of bladder urothelium |
Present |
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2_right Upk3b lower -/-
,
2_right Upk3b upper -/-
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A thickened and ruffled epithelium with reduced and patchy expression and luminal shedding, compared with the wild-type.
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Analysis Tools