Cldn1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:228856 DiTommaso T, et al., Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet. 2014 Oct;10(10):e1004706
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6456592
Gene symbol:	Cldn1
Gene name:	claudin 1

Antibody:	claudin-1 antibody (ab15098)
Assay notes:	Two antibodies were described, but the one used in this assay was not detailed. Claudin-1 antibody MGI:6456184 may have been used in this assay.

Results

5D +/+ ©

Specimen 5D +/+: postnatal adult (more

)
Note: Triple labeled: green - Cldn1; red - ECAD (Cdh1; assay MGI:6696419); blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: metapodial pad	Present		5D +/+

5D tm1a/tm1a ©

Specimen 5D tm1a/tm1a: postnatal adult; Krt76^{tm1a(KOMP)Wtsi}/Krt76^{tm1a(KOMP)Wtsi} (more

)
Note: Triple labeled: green - Cldn1; red - ECAD (Cdh1; assay MGI:6696419); blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: metapodial pad	Present	Regionally restricted	5D tm1a/tm1a

5G +/+ ©

Specimen 5G +/+: postnatal adult (more

)
Note: Double labeled: green - Cldn1; blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: back skin	Present		5G +/+

5G tm1a/tm1a ©

Specimen 5G (Early): postnatal adult; Krt76^{tm1a(KOMP)Wtsi}/Krt76^{tm1a(KOMP)Wtsi} (more

)
Note: Double labeled: green - Cldn1; blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: back skin	Present	Regionally restricted	5G tm1a/tm1a	Authors report mislocalization of membranous expression.

S2E +/+ ©

Specimen S2E +/+: postnatal adult (more

)
Note: Double labeled: red - Cldn1; blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: metapodial pad epidermis	Present		S2E +/+

S2E No wound ©

Specimen S2E No wound: postnatal adult; Krt76^{tm1a(KOMP)Wtsi}/Krt76^{tm1a(KOMP)Wtsi} (more

)
Note: Double labeled: red - Cldn1; blue - DAPI.

Structure	Level	Pattern	Image	Note
TS28: metapodial pad epidermis	Present		S2E No wound

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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