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Gene Expression Data
Assay Details
Assay
Reference: J:287334 Wunnemann F, et al., Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. Nat Genet. 2020 Jan;52(1):40-47
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6437246
Gene symbol: Adamts19
Gene name: ADAM metallopeptidase with thrombospondin type 1 motif 19
Reporter: lacZ
Direct Detection
Results
Specimen 5A: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: left atrium Present 5A
TS23: right atrium Present 5A
TS23: ventricle cardiac muscle Present 5A Expression is seen in trabeculated myocardium.
Specimen 5B: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: left atrium Present 5B
TS27: right atrium Present 5B
TS27: ventricle cardiac muscle Present 5B Expression is seen in trabeculated myocardium.
Specimen 5C: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: left atrium Present 5C
TS28: right atrium Present 5C
TS28: ventricle cardiac muscle Present 5C Expression is seen in trabeculated myocardium.
Specimen 5D: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: tricuspid valve Present 5D Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5E: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: tricuspid valve Present 5E Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5F: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: tricuspid valve Present 5F Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5G: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: mitral valve Present 5G Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5H: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: mitral valve Present 5H Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5I: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: mitral valve Present 5I Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5J: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: pulmonary valve Present 5J Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5K: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: pulmonary valve Present 5K Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5L: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: pulmonary valve Present 5L Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5M: embryonic day 15.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS23: aortic valve Present 5M Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5N: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: pulmonary valve Present 5N Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen 5O: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: aortic valve Present 5O Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen S7A: embryonic day 10.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS17: heart Absent S7A
TS17: cartilage condensation Weak S7A Weak staining is observed at regions of cartilage formation.
Specimen S7B: embryonic day 12.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS20: bone Strong S7B Strong staining is present in the developing bones and joints.
TS20: skeletal system Strong S7B Strong staining is present in the developing bones and joints.
Specimen S7C: embryonic day 12.5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS20: endocardial cushion Weak Diffuse S7C
TS20: left atrium Weak Diffuse S7C
TS20: left ventricle cardiac muscle Weak Diffuse S7C Expression is seen in the trabeculated myocardium.
Specimen S8A: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: left atrium Present S8A
TS27: right atrium Present S8A
TS27: heart left ventricle Present S8A
TS27: heart right ventricle Present S8A
Specimen S8B: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: left atrium Present S8B
TS28: right atrium Present S8B
TS28: heart left ventricle Absent S8B
TS28: heart right ventricle Absent S8B
Specimen S8C: postnatal month 5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: left atrium Present S8C
TS28: right atrium Present S8C
Specimen S8D: postnatal day 1; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS27: aortic valve Strong S8D Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS27: mitral valve Strong S8D Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS27: pulmonary valve Strong S8D Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS27: tricuspid valve Strong S8D Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen S8E: postnatal day 21; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: aortic valve Present S8E Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: mitral valve Present S8E Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: pulmonary valve Present S8E Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: tricuspid valve Present S8E Expression is detected in the interstitial cells, not in the endothelial monolayer.
Specimen S8F: postnatal month 5; Adamts19tm4b(EUCOMM)Wtsi/Adamts19tm4b(EUCOMM)Wtsi (more )
Note: The authors used two alleles interchangeably for these studies; it is possible the tm4a allele (MGI:5527601) was used to obtain these results.
Structure Level Pattern Image Note
TS28: aortic valve Present S8F Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: mitral valve Present S8F Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: pulmonary valve Present S8F Expression is detected in the interstitial cells, not in the endothelial monolayer.
TS28: tricuspid valve Present S8F Expression is detected in the interstitial cells, not in the endothelial monolayer.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
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