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Gene Expression Data
Assay Details
Assay
Reference: J:287264 Hael CE, et al., The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight. Mol Metab. 2020 Apr;34:43-53
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6436933
Gene symbol: Prdm12
Gene name: PR domain containing 12
Reporter: lacZ
Direct Detection
Results
Specimen 2A upper: embryonic day 13.5; Prdm12tm2b(EUCOMM)Hmgu/Prdm12+ (more )
Note: lateral view
Structure Level Pattern Image Note
TS21: trigeminal ganglion Present 2A upper
TS21: brain Present 2A upper
Specimen 2A lower: embryonic day 13.5; Prdm12tm2b(EUCOMM)Hmgu/Prdm12+ (more )
Note: dorsal view
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present 2A lower
TS21: brain Present 2A lower
Specimen 2B +/-: embryonic day 13.5; Prdm12tm2b(EUCOMM)Hmgu/Prdm12+ (more )
Note: Double labeled: blue - Prdm12; brown - Pomc (assay MGI:6436934)
Structure Level Pattern Image Note
TS21: hypothalamus Present Regionally restricted 2B +/- inset , 2B +/- Staining is prominent in the basal hypothalamus (future arcuate nucleus).
TS21: pituitary gland Absent 2B +/- There is no staining in Rathke's pouch.
Specimen 2B -/-: embryonic day 13.5; Prdm12tm2b(EUCOMM)Hmgu/Prdm12tm2b(EUCOMM)Hmgu (more )
Note: Double labeled: blue - Prdm12; brown - Pomc (assay MGI:6436934)
Structure Level Pattern Image Note
TS21: hypothalamus Present Regionally restricted 2B -/- , 2B -/- inset Staining is prominent in the basal hypothalamus (future arcuate nucleus).
TS21: pituitary gland Absent 2B -/- There is no staining in Rathke's pouch.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory