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Gene Expression Data
Assay Details
Assay
Reference: J:227662 Luo Y, et al., MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway. Genesis. 2015 Nov;53(11):678-84
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6436306
Gene symbol: Ddx4
Gene name: DEAD box helicase 4
Antibody: Anti-DDX4/MVH (ab13840)
Detection system: Secondary antibody
Results
Specimen 1a E13.5 WT M: embryonic day 13.5 (more )
Note: Data was quantified in Fig 1b.
Structure Level Pattern Image Note
TS21: germ cell of testis Present 1a male bottom left
Specimen 1a E13.5 XG/XG M: embryonic day 13.5; Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 1b.
Structure Level Pattern Image Note
TS21: germ cell of testis Present 1a male bottom right Significant decrease of primordial germ cells, compared with the wild-type.
Specimen 1a E13.5 WT F: embryonic day 13.5 (more )
Note: Data was quantified in Fig 1b.
Structure Level Pattern Image Note
TS21: germ cell of ovary Present 1a female bottom left
Specimen 1a E13.5 XG/XG F: embryonic day 13.5; Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 1b.
Structure Level Pattern Image Note
TS21: germ cell of ovary Present 1a female bottom right Significant decrease of primordial germ cells, compared with the wild-type.
Specimen not shown WT M: postnatal day 1 (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of testis Present
Specimen not shown WT F: postnatal day 1 (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present
Specimen not shown XG/XG M: postnatal day 1; Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of testis Present Significant decrease of primordial germ cells, compared with the wild-type.
Specimen not shown XG/XG F: postnatal day 1; Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present Significant decrease of primordial germ cells, compared with the wild-type.
Specimen not shown XG/XG;p21-/- M: postnatal day 1; Cdkn1atm1Tyj/Cdkn1atm1Tyj, Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of testis Present Significant decrease of primordial germ cells, compared with the wild-type. Cdkn1a deficiency did not rescue germ cell depletion.
Specimen not shown XG/XG;p21-/- F: postnatal day 1; Cdkn1atm1Tyj/Cdkn1atm1Tyj, Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present Significant decrease of primordial germ cells, compared with the wild-type. Cdkn1a deficiency did not rescue germ cell depletion.
Specimen not shown XG/XG;Atm-/- M: postnatal day 1; Atmtm1Led/Atmtm1Led, Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of testis Present Significant decrease of primordial germ cells, compared with the wild-type. Atm deficiency did not rescue germ cell depletion.
Specimen not shown XG/XG;Atm-/- F: postnatal day 1; Atmtm1Led/Atmtm1Led, Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present Significant decrease of primordial germ cells, compared with the wild-type. Atm deficiency did not rescue germ cell depletion.
Specimen not shown XG/XG;Chk2-/- M: postnatal day 1; Chek2tm1Mak/Chek2tm1Mak, Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of testis Present Significant decrease of primordial germ cells, compared with the wild-type. Chek2 deficiency did not rescue germ cell depletion.
Specimen not shown XG/XG;Chk2-/- F: postnatal day 1; Chek2tm1Mak/Chek2tm1Mak, Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 2.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present Significant decrease of primordial germ cells, compared with the wild-type. Chek2 deficiency did not rescue germ cell depletion, Although there was an increased number of germ cells, compared with the single mutants.
Specimen not shown WT M: postnatal newborn (more )
Note: Data was quantified in Fig 3.
Structure Level Pattern Image Note
TS27: germ cell of testis Present
Specimen not shown WT F: postnatal newborn (more )
Note: Data was quantified in Fig 3.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present
Specimen not shown XG/XG M: postnatal newborn; Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 3.
Structure Level Pattern Image Note
TS27: germ cell of testis Present Significant decrease of primordial germ cells, compared with the wild-type.
Specimen not shown XG/XG F: postnatal newborn; Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 3.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present Significant decrease of primordial germ cells, compared with the wild-type.
Specimen not shown C4/C4 M: postnatal newborn; FancmChaos4/FancmChaos4 (more )
Note: Data was quantified in Fig 3.
Structure Level Pattern Image Note
TS27: germ cell of testis Present Decrease of primordial germ cells, compared with the wild-type.
Specimen not shown C4/C4 F: postnatal newborn; FancmChaos4/FancmChaos4 (more )
Note: Data was quantified in Fig 3.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present Decrease of primordial germ cells, compared with the wild-type.
Specimen not shown XG/XG;C4/C4 M: postnatal newborn; FancmChaos4/FancmChaos4, Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 3.
Structure Level Pattern Image Note
TS27: germ cell of testis Present The double mutants had significantly fewer germ cells at birth compared to either single mutant.
Specimen not shown XG/XG;C4/C4 F: postnatal newborn; FancmChaos4/FancmChaos4, Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg (more )
Note: Data was quantified in Fig 3.
Structure Level Pattern Image Note
TS27: germ cell of ovary Present The double mutants had significantly fewer germ cells at birth compared to either single mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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