Summary | Transgene origin | Transgene description | Find Mice (IMSR) | Notes | References

Symbol:	Tg(SERPINA1*E342K)Z11.03Slcw
Name:	transgene insertion Z11.03, Savio L C Woo
MGI ID:	MGI:6435699
Synonyms:	PiZ
Transgene:	Tg(SERPINA1*E342K)Z11.03Slcw  Location: unknown
Alliance:	Tg(SERPINA1*E342K)Z11.03Slcw page

Strain of Origin:

(ICR x C57BL/6)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Nucleotide substitutions   Tg(SERPINA1*E342K)Z11.03Slcw expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SERPINA1 (5265) Serpina1a  (MGI:891971) Serpina1b  (MGI:891970) Serpina1c  (MGI:891969) Serpina1d  (MGI:891968) Serpina1e  (MGI:891967) expresses the E342K mutation   Mutation details: The transgenic construct contains the entire mutant human SERPINA1 (serine (or cysteine) peptidase inhibitor, clade A, member 1 cluster) gene under its endogenous promoter plus 2 kB of the 5' and 3' flanking genomic DNA sequences. Mutant SERPINA1 contains the PiZ variant in which glutamic acid is replaced by lysine at residue 342 (CAG to AAG, E342K). Founder Z11.03 carrying 16 copies of the transgene. (J:149132, J:149133)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:149132 Carlson JA, et al., Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice. J Clin Invest. 1989 Apr;83(4):1183-90
All:	5 reference(s)