Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Gtf2ird1em3Jdd
Name:	general transcription factor II I repeat domain-containing 1; endonuclease-mediated mutation 3, Joseph D Dougherty
MGI ID:	MGI:6429892
Synonyms:	Gtf2ird1em1bpins
Gene:	Gtf2ird1  Location: Chr5:134386510-134485570 bp, - strand  Genetic Position: Chr5, 74.55 cM
Alliance:	Gtf2ird1em3Jdd page

Strain of Origin:

FVB/N

Allele Type:    Endonuclease-mediated (Hypomorph) Mutation:    Insertion   Mutation details: CRISPR/cas9 endonuclease-mediated genome editing was used to create a 1 bp adenine insertion in exon 3 of the gene. The deletion causes a frameshift mutation that introduces a premature stop codon. The resulting N-truncated protein has diminished binding capacity. There is a 40% reduction of protein in homozygotes. (J:94077)

In Mice Carrying this Mutation:

22 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gtf2ird1 Mutation:	358 strains or lines available

Original:	J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:	3 reference(s)