Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:203431
Collette NM, et al., Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. Dev Biol. 2013 Nov 1;383(1):90-105
|
|
Assay type:
|
In situ reporter (knock in)
|
|
MGI Accession ID:
|
MGI:6406285
|
|
Gene symbol:
|
Sostdc1
|
|
Gene name:
|
sclerostin domain containing 1
|
|
Reporter:
|
lacZ
|
|
|
Direct Detection
|
|
|
Results
|
Specimen
2G:
(close  )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2H:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 10.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2H':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 10.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS17: forelimb bud |
Present |
Regionally restricted |
2H'
|
Expression in small field of ectoderm on posterior side of limb.
|
Specimen
2h:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 10.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS17: forelimb bud ectoderm |
Present |
Regionally restricted |
2h
|
Expression in ectoderm on posterior side of limb.
|
Specimen
2I:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2I':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: forelimb bud |
Strong |
Regionally restricted |
2I'
|
Strong expression primarily in meesnchyme of proximal limb.
|
Specimen
2i:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS19: forelimb bud mesenchyme |
Strong |
Regionally restricted |
2i
|
Strong expression primarily in meesnchyme of proximal limb.
|
Specimen
2i':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 11.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
2J:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 12.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS20: embryo |
Present |
Regionally restricted |
2J
|
Experssion in cartilage template outlining vertebrae, ribs and digits.
|
Specimen
2J':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 12.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2j:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 12.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS20: hand |
Present |
Regionally restricted |
2j
|
|
Specimen
2j':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 12.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
2K:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 13.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS21: embryo |
Present |
Regionally restricted |
2K
|
Expression domain expands.
|
Specimen
2K':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 13.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS21: hand |
Present |
Regionally restricted |
2K'
|
Expression domain intensifies in proximal limb.
|
| TS21: forelimb digit |
Present |
Regionally restricted |
2K'
|
Expression domain surrounds condensing cartilage anlage.
|
Specimen
2L:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 14.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2L':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
embryonic day 14.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
3A':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: limb connective tissue |
Present |
Widespread |
3A'
|
Broadly expressed in limbs encompassing connective tissue, muscle, cartilage and neurons.
|
| TS27: limb musculature |
Present |
Widespread |
3A'
|
Broadly expressed in limbs encompassing connective tissue, muscle, cartilage and neurons.
|
| TS27: limb nerve |
Present |
Widespread |
3A'
|
Broadly expressed in limbs encompassing connective tissue, muscle, cartilage and neurons.
|
Specimen
3B':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
3C':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
3c':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
3D':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
3E':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: cranium |
Present |
|
3E'
|
Expression in skull.
|
Specimen
3e':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: connective tissue |
Present |
Regionally restricted |
3e'
|
Expression in connective tissue over calvarial bones. Expression in membrane overlying calvaria.
|
Specimen
3F':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: connective tissue |
Present |
Regionally restricted |
3F'
|
Expression in connective tissue surrounding the mandible.
|
Specimen
neonatal not shown:
postnatal newborn; Sostdc1tm1Myan/Sostdc1 +
(more  )
Specimen
neonatal not shown:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal newborn
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: genitourinary system |
Present |
|
|
Authors report expression in kidney and in urogenital system in neonates.
|
| TS27: metanephros |
Present |
|
|
Authors report expression in kidney and in urogenital system in neonates.
|
Specimen
S2F:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
S2f:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
4A:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
4a:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
4a':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
4B:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: brain |
Present |
Regionally restricted |
4B
|
Expression in highly specialized region of brain.
|
Specimen
4B':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: brain |
Present |
Regionally restricted |
4B'
|
Expression in highly specialized region of brain.
|
Specimen
4C:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: stomach |
Present |
Regionally restricted |
4C
|
Expression in smooth muscle of stomach.
|
Specimen
4C':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
4D:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: intestine |
Present |
Regionally restricted |
4D
|
Expression in smooth muscle of intestine.
|
Specimen
4D':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
4E:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
4E':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
4F:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
4F':
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
4G:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
4H:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
4I:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: nerve |
Present |
Regionally restricted |
4I
|
Expression in neurons.
|
Specimen
4J:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
4K:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Embedding:
|
Paraffin
|
Specimen
4L:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
adult not shown:
postnatal adult; Sostdc1tm1Myan/Sostdc1 +
(more )
Specimen
adult not shown:
(close )
|
Genetic Background:
|
involves: 129/SvJ * C57BL/6
|
|
Mutant Allele(s):
|
Sostdc1tm1Myan/Sostdc1+
|
|
Age:
|
postnatal adult
|
|
Sex:
|
Not Specified
|
|
Type:
|
Not Specified
|
|
Fixation:
|
4% Paraformaldehyde
|
|
Analysis Tools