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Drd2tm1.1Jtw
Targeted Allele Detail
Summary
Symbol: Drd2tm1.1Jtw
Name: dopamine receptor D2; targeted mutation tm1.1, John Williams
MGI ID: MGI:6406268
Synonyms: GFP-D2
Gene: Drd2  Location: Chr9:49251927-49319477 bp, + strand  Genetic Position: Chr9, 26.72 cM
Alliance: Drd2tm1.1Jtw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:286658
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsA superecliptic pHluorin (SpH) with a human prolactin hormone signal sequence was introduced to exon 2 of the mouse Drd2 gene, enabling the expression of a fused GFP-D2R protein. A loxP-flanked PGK-neomycin cassette was placed in intron 2. Cre-mediated recombination removed the floxed neo cassette. (J:286658)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  70 strains or lines available
References
Original:  J:286658 Robinson BG, et al., Desensitized D2 autoreceptors are resistant to trafficking. Sci Rep. 2017 Jun 29;7(1):4379
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory