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Clec14atm1Ygk
Targeted Allele Detail
Summary
Symbol: Clec14atm1Ygk
Name: C-type lectin domain family 14, member a; targeted mutation 1, Young-Guen Kwon
MGI ID: MGI:6404416
Gene: Clec14a  Location: Chr12:58311506-58316044 bp, - strand  Genetic Position: Chr12, 25.65 cM
Alliance: Clec14atm1Ygk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:239835
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA beta-galactosidase gene and loxP-flanked neomycin selection cassette replaced the entire gene while retaining upstream and downstream regulators through homologous recombination. Western blot analysis confirmed absence of protein in lung lysates. (J:239835)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clec14a Mutation:  32 strains or lines available
References
Original:  J:239835 Lee S, et al., Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest. 2017 Feb 01;127(2):457-471
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory