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Gene Expression Data
Assay Details
Assay
Reference: J:139570 Capellini TD, et al., Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev Biol. 2008 Sep 15;321(2):500-14
Assay type: RNA in situ
MGI Accession ID: MGI:6391095
Gene symbol: Sox9
Gene name: SRY (sex determining region Y)-box 9
Probe: Sox9 cDNA3
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 7D Sox9 E12 WT: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: vertebral cartilage condensation Present 7D Sox9 E12 WT Expression in vertebral bodies.
TS20: rib pre-cartilage condensation Present 7D Sox9 E12 WT Expression in areas where ribs form.
Specimen 7D Sox9 E12 Pbx1-/-;Pbx1-/-: embryonic day 12.0; Pbx1tm1Mlc/Pbx1tm1Mlc, Pbx2tm1Mlc/Pbx2+ (more )
Structure Level Pattern Image Note
TS20: vertebral cartilage condensation Present 7D Sox9 E12 Pbx1-/-;Pbx2+/- Expression in vertebral bodies relatively unchanged compared to wild type.
TS20: rib pre-cartilage condensation Absent 7D Sox9 E12 Pbx1-/-;Pbx2+/- Expression absent in areas where ribs should form.
Specimen 7D Sox9 Cerv-Thor E12 WT: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: vertebral cartilage condensation Present 7D Sox9 E12 Cerv-Thor WT Expression in vertebral bodies.
Specimen 7D Sox9 Cerv-Thor E12 Pbx1-/-;Pbx2+/-: embryonic day 12.0; Pbx1tm1Mlc/Pbx1tm1Mlc, Pbx2tm1Mlc/Pbx2+ (more )
Structure Level Pattern Image Note
TS20: vertebral cartilage condensation Present 7D Sox9 E12 Cerv-Thor Pbx1-/-;Pbx2+/- Expression in vertebral bodies relatively unchanged compared to wild type.
Specimen 7D Sox9 Thor E13 WT: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: thoracic vertebral cartilage condensation Present Regionally restricted 7D Sox9 E13 Thor WT Expression in thoracic vertebral body mesenchyme. Expression in thoracic neural arches.
Specimen 7D Sox9 Thor E13 Pbx1-/-;Pbx2+/-: embryonic day 13.0; Pbx1tm1Mlc/Pbx1tm1Mlc, Pbx2tm1Mlc/Pbx2+ (more )
Structure Level Pattern Image Note
TS21: thoracic vertebral cartilage condensation Present Regionally restricted 7D Sox9 E13 Thor Pbx1-/-;Pbx2+/- Expression slightly reduced in thoracic vertebral body mesenchyme compared to wild type. Strong expression in thoracic neural arches.
Specimen 7D Sox9 Caud E13 WT: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: notochord Present 7D Sox9 E13 Caud WT Expression in caudal neural arches, caudal body mesenchyme and notochord.
TS21: tail mesenchyme Present 7D Sox9 E13 Caud WT Expression in caudal neural arches, caudal body mesenchyme and notochord.
TS21: tail vertebral cartilage condensation Present 7D Sox9 E13 Caud WT Expression in caudal neural arches, caudal body mesenchyme and notochord.
Specimen 7D Sox9 Caud E13 Pbx1-/-;Pbx2+/-: embryonic day 13.0; Pbx1tm1Mlc/Pbx1tm1Mlc, Pbx2tm1Mlc/Pbx2+ (more )
Structure Level Pattern Image Note
TS21: notochord Strong 7D Sox9 E13 Caud Pbx1-/-;Pbx2+/- Strong expression in caudal neural arches, caudal body mesenchyme and notochord.
TS21: tail mesenchyme Strong 7D Sox9 E13 Caud Pbx1-/-;Pbx2+/- Strong expression in caudal neural arches, caudal body mesenchyme and notochord.
TS21: tail vertebral cartilage condensation Strong 7D Sox9 E13 Caud Pbx1-/-;Pbx2+/- Strong expression in caudal neural arches, caudal body mesenchyme and notochord.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory