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Gene Expression Data
Assay Details
Assay
Reference: J:166528 Zacharias AL, et al., Canonical Wnt/beta-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. Dev Dyn. 2010 Dec;239(12):3215-25
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6388683
Gene symbol: Foxc2
Gene name: forkhead box C2
Antibody: Foxc2 antibody
Detection system: Biotinylated secondary antibody/[Strept]avidin
Results
Specimen 6E: embryonic day 12.5; Ctnnb1tm2Kem/Ctnnb1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Littermate control; embryo was either fl/fl or fl/+.
Structure Level Pattern Image Note
TS20: perioptic mesenchyme Present Regionally restricted 6E Expression in neural crest of periocular mesenchyme.
TS20: cornea Weak Regionally restricted 6E Expression downregulated in corneal neural crest.
TS20: eye epithelium Present Regionally restricted 6E Expresison in surface ectoderm of palpebral conjunctiva.
Specimen 6F: embryonic day 12.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: eye epithelium Present Regionally restricted 6F Expression patterns in both neural crest and palpebral conjunctiva conserved in mutant.
TS20: perioptic mesenchyme Present Regionally restricted 6F Expression patterns in both neural crest and palpebral conjunctiva conserved in mutant.
Specimen 6G: embryonic day 14.5; Ctnnb1tm2Kem/Ctnnb1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Littermate control; embryo was either fl/fl or fl/+.
Structure Level Pattern Image Note
TS22: perioptic mesenchyme Present Regionally restricted 6G Expression in neural crest of periocular mesenchyme.
TS22: cornea Weak Regionally restricted 6G Expression downregulated in corneal neural crest.
TS22: conjunctiva epithelium Present Regionally restricted 6G Expression in surface ectoderm of palpebral conjunctiva.
Specimen 6H: embryonic day 14.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: conjunctiva epithelium Present Regionally restricted 6H Expression patterns in both neural crest and palpebral conjunctiva conserved in mutant.
TS22: perioptic mesenchyme Present Regionally restricted 6H Expression patterns in both neural crest and palpebral conjunctiva conserved in mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory