Ror2 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:213602 Arora R, et al., Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug;243(8):1037-45
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6379384
Gene symbol:	Ror2
Gene name:	receptor tyrosine kinase-like orphan receptor 2

Antibody:	anti-hROR2
Detection system:	Alexa Fluor

Results

3A Merge ©

3A Ror2 ©

Specimen 3A: embryonic day 12.5 (more

)
Note: Double labeled: red - Ror2; gray - E-Cad (Cdh1 assay MGI:6379385).

Structure	Level	Pattern	Image	Note
TS20: lung epithelium	Present	Regionally restricted	3A Ror2 , 3A Merge	Expression in membrane of branching epithelial cells.

3B Merge ©

3B Ror2 ©

Specimen 3B: embryonic day 12.5; Ror2^tm1.1Meg/Ror2^tm1.1Meg, Tg(Zp3-cre)82Knw/0 (more

)
Note: Conditional mutant. Double labeled: red - Ror2; gray - E-Cad (Cdh1 assay MGI:6379385).

Structure	Level	Pattern	Image	Note
TS20: lung epithelium	Absent		3B Merge , 3B Ror2

4C ©

Specimen 4C: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: testis	Present	Regionally restricted	4C

4C' ©

Specimen 4C': embryonic day 18.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: germ cell of testis		Present	Regionally restricted	4C'	Expression on membranes of germ cells and Sertoli cells.
TS26: Sertoli cell	Sertoli cell	Present	Regionally restricted	4C'	Expression on membranes of germ cells and Sertoli cells.

4D ©

Specimen 4D: embryonic day 18.5; Ror2^tm1.1Meg/Ror2^tm1.1Meg, Tg(Zp3-cre)82Knw/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS26: testis	Ambiguous		4D

4D' ©

Specimen 4D': embryonic day 18.5; Ror2^tm1.1Meg/Ror2^tm1.1Meg, Tg(Zp3-cre)82Knw/0 (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS26: germ cell of testis		Absent		4D'
TS26: Sertoli cell	Sertoli cell	Absent		4D'

5A ©

Specimen 5A: embryonic day 12.5 (more

)
Note: Double labeled: red - Ror2; gray - SSEA1 (Fut4 assay MGI:6379387).

Structure	Level	Pattern	Image	Note
TS20: ovary	Present	Regionally restricted	5A

5A' (left) ©

5A' (right) ©

Specimen 5A': embryonic day 12.5 (more

)
Note: Double labeled: red - Ror2; gray - SSEA1 (Fut4 assay MGI:6379387).

Structure	Level	Pattern	Image	Note
TS20: germ cell of ovary	Present	Regionally restricted	5A' (left) , 5A' (right)	Expression on membrane of germ cells.
TS20: mesenchymal stroma of ovary	Present	Regionally restricted	5A' (right) , 5A' (left)	Expression in surrounding suport cells in mesenchyme in a salt-and-pepper-like pattern

5B ©

Specimen 5B: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: ovary	Present		5B

5C ©

Specimen 5C: embryonic day 14.5; Ror2^tm1.1Meg/Ror2^tm1.1Meg, Tg(Zp3-cre)82Knw/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: ovary	Absent		5C

5E (center) ©

5E (left) ©

5E merge ©

Specimen 5E: embryonic day 15.5 (more

)
Note: Triple labeled: red - Ror2; gray - Foxl2 (assay MGI:6379387); green - E-Cad (Cdh1 assay MGI:6379385).

Structure	Level	Pattern	Image	Note
TS23: ovary	Present	Regionally restricted	5E (center) , 5E (left) , 5E merge

5E' (left) ©

5E' (right) ©

Specimen 5E': embryonic day 15.5 (more

)
Note: Triple labeled: red - Ror2; gray - Foxl2 (assay MGI:6379387); green - E-Cad (Cdh1 assay MGI:6379385).

Structure	Level	Pattern	Image	Note
TS23: germ cell of ovary	Ambiguous		5E' (left) , 5E' (right)	Expression downregulated in germ cells.
TS23: mesenchymal stroma of ovary	Present	Regionally restricted	5E' (right) , 5E' (left)	Expression in granulosa cells.

6A (left) ©

6A (right) ©

Specimen 6A: postnatal day 0 (more

)
Note: Double labeled: red - Ror2; gray - E-Cad (Cdh1 assay MGI:6379385).

Structure	Level	Pattern	Image	Note
TS27: epididymis	Present		6A (right) , 6A (left)

6A inset ©

Specimen 6A inset: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: epithelium of epididymis	Present	Regionally restricted	6A inset	Expression in epithelium of epididymal ducts.

6B (left) ©

6B (right) ©

Specimen 6B: postnatal day 21 (more

)

Structure	Level	Pattern	Image	Note
TS28: epididymis	Present		6B (left) , 6B (right)

6C (left) ©

6C (right) ©

Specimen 6C: postnatal adult (more

)
Note: Double labeled: red - Ror2; gray - E-Cad (Cdh1 assay MGI:6379385).

Structure	Level	Pattern	Image	Note
TS28: uterus	Present		6C (left) , 6C (right)
TS28: female reproductive system	Present	Regionally restricted	6C (right) , 6C (left)	Expression in ductal structures derived from the Mullerian duct

6C inset ©

Specimen 6C inset: postnatal adult (more

)

Structure	Level	Pattern	Image	Note
TS28: female reproductive system epithelium	Present	Regionally restricted	6C inset	Epithelial expression in ductal derivatives.

6D (left) ©

6D (right) ©

Specimen 6D: postnatal adult (more

)
Note: Double labeled: red - Ror2; gray - E-Cad (Cdh1 assay MGI:6379385).

Structure	Level	Pattern	Image	Note
TS28: female reproductive system epithelium	Present	Regionally restricted	6D (left) , 6D (right)	Expression in duct-derived epithelia surrounding the ovary.

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